Handbook of Free Radicals and Antioxidants in Biomedicine

Jaime Miquel, Ph.D. presently holds the position of Research Associate at the Linus Pauling Institute of Science and Medicine in Alicante. Alexandre T. Quintanilha, Ph.D., D.Sc., is Director of the Center for Atmosphere and Biospheric Effects of Technology and Assistant Head of the Applied Science Division at the Lawrence Berkeley Laboratory. Hans U. Weber, Ph.D., in 1987 joined the Medical Writing Group of Syntex Rsearch, Palo Alto, California.

Introduction Historical Introduction to Free Radical and Antioxidant Biomedical Research. Physicochemical and Physiological Aspects Chemical and Biochemical Aspects of Activated Oxygen: Singlet, Superoxide Antion, and Related Species. Formation of Electronically Excited States in Biological Systems: Contribution of Singlet Oxygen and Excited Carbonyl Compounds to Biological Chemiluminescence. Role of Metals in Oxygen Radical Reactions and Oxidative Stress. Peroxides: Physiological Function and Role in Drug Toxicity and Carcinogen Activation. Pro-Oxidant Action of Antioxidants. The Role of Free Radicals in the Cytotoxicity of Cysteine. Generation of Oxygen Radicals by the Anticancer Quinone Drugs Adrianycin, Aclacinomycin A, Carbazilquinone, and Mitomycin C in NADPH-Cytochrome P-450 Reductase and Xanthine Oxidase Systems. Thyroid Hormone, Active Oxygen, and Lipid Peroxidation. Effects of Oxygen Radicals and Antioxidants on Calcium Ion Transport across Lipid Bilayers and Cellular Membranes. Leukotrienes and Related Substances: Inflammatory and Pharmacological Effects. Free Radicals from Catecholamine Hormones, Neuromelanins, and Neurotoxins. Membrane Phospholipids Modulate Synaptic GABA Receptor Binding through the Generation of Active Oxygen Radicals. Free Radicals, Peroxides, Aging, and Disease. Free Radicals and Lipid Peroxidation in Cell Pathology. Free Radical-Induced Lipoperoxidation and Aging. Functional Consequences of Free Radical Damage to Cell Membranes. Free Radicals and Human Disease. Serum Lipid Peroxide Levels in Subjects Having Certain Diseases and in Aging. Neutrophil-Induced Erythrocyte Injury. Plasma Lipid Peroxides in Patients with Vascular Disease and in Middle-Aged Normal Subjects with a High Risk of Atherosclerosis. Neutrophil Infiltration of the Myocardium: A Potential Mechanism for Free Radical Necrosis. Xanthine Oxidase, Free Radicals, and Myocardial Ischemia. The Role of Oxygen-Derived Free Radicals in the Pathogenesis of Myocardial Ischemia and Reperfusion Induced Injury. The Role of Free Radicals in Drug-Induced Myocardial Effects. Involvement of Oxygen Radicals in Pulmonary Edema. Free radical Lipid Peroxidation in Rheumatoid Arthritis.