Protein–Protein Interaction Regulators

Introduction;

Protein-protein interaction interfaces and their functional implications;

Protein-Protein interaction networks in human disease;

High Throughput Screening Methods for PPI inhibitor discovery;

Computational structural modeling to discover PPI modulators;

Small molecule inhibitors of E3 ubiquitin ligases;

Hydrogen bond surrogate stabilized helices as Protein-Protein interaction inhibitors;

Helix-mimetics as Protein-Protein Interaction Inhibitors;

Discovery and Development of Mcl-1 Inhibitors as Anti-cancer Therapeutics: Hit to Clinical Candidate Optimization;

Pharmacological Regulation and Functional Significance of Chromatin Binding by BET Tandem Bromodomains;

Small-molecule modulators of Protein-Protein Interactions: focus on 14-3-3 PPIs;

Discovery of AMG 232, a small molecule MDM2 inhibitor in clinical development and its back-up clinical candidate, AM-7209;

Small Molecule Inhibitors of Myc-Max Interaction and DNA Binding;

Small Molecule Modulators of Endo-Lysosomal Toll-Like Receptors