Protein Surface Recognition (eBook)

ERNEST GIRALT, Department of Organic Chemistry, University of Barcelona and Institute for Research in Biomedicine, Barcelona, Spain MARK PECZUH, Department of Chemistry, University of Connecticut, USA XAVIER SALVATELLA, ICREA and Institute for Research in Biomedicine, Barcelona, Spain

Preface

List of Contributors

SECTION A. PRINCIPLES

1 The discovery and characterization of protein-protein interactions

C. Bertoncini, A. Higueruelo, and Xavi Salvatella

2 Biophysics of protein-protein interactions

Irene Luque

SECTION B. APPROACHES

3 On the logic of natural product binding in protein-protein interactivity

James J. La Clair

4 Interface peptide inhibitors of PPIs

Mark W. Peczuh, and Richard T. Desmond

5 Inhibition of protein-protein interactions by peptide mimics

Jorge Becerril, Johanna M. Rodriguez, Pauline N. Wyrembak, and Andrew D. Hamilton

6 Discovery of inhibitors of protein-protein interactions by screening chemical libraries

Carlos García-Echeverría

SECTION C. TECHNIQUES

7 High-throughput methods of chemical synthesis applied to the Preparation of inhibitors of protein-protein interactions

Annaliese K. Franz, Jared T. Shaw, and Yuchen Tang

8 In silico screening

F.J. Luque, and Xavier Barril

9.1 In vitro and in vivo screening: Screening by Nuclear Magnetic Resonance

Ernest Giralt

9.2 In vitro and in vivo screening: Methods of High Throughput Screening

Wenjiao Song and Qing Lin

SECTION D. CASE STUDIES

10 Case Study: Inhibitors of the MDM2-p53 protein-protein interaction

Sanjeev Shangary, Denzil Bernard, and Shaomeng Wang

11 Case Study: The Discovery of Potent LFA-1 Antagonists

Tom Gadek

Index

"This book picks up this trend and provides an excellent overview
of the current topics in the field of PPI modulation by small
molecules and peptides. . . Taken together, this excellent book is
very suitable both as an introduction to the field, as well as a
compendium for readers already familiar with the chemical approach
of modulating PPIs." (ChemMedChem, 2011)