Quantification of Biophysical Parameters in Medical Imaging (eBook)
VIII, 497 Seiten
Springer International Publishing (Verlag)
978-3-319-65924-4 (ISBN)
This book provides a selection of essential knowledge on the image-based quantification of biophysical parameters for the purpose of clinical diagnosis. The authors regard clinical imaging scanners as physical measurement systems capable of quantifying intrinsic parameters for depiction of the constitution and biophysical properties of in vivo tissue. On the one hand, this approach supports the development of new methods of imaging highly reproducible, system-independent, and quantitative biomarkers, and these methods receive detailed attention in the book. On the other hand, the reader will also gain a deeper understanding of how physical tissue properties interact with the generation of signals in medical imaging, opening new windows on the intricate and fascinating relationship between the structure and function of living tissues. The book will be of interest to all who recognize the limitations of basing clinical diagnosis primarily on visual inspection of images and who wish to learn more about the diagnostic potential of quantitative and biophysics-based medical imaging markers and the challenges that the paucity of such markers poses for next-generation imaging technologies.
Ingolf Sack is a Heisenberg professor of the German Research Foundation for Experimental Radiology and Elastography at Charité-Universitätsmedizin Berlin, Germany. He received a PhD in Chemistry from Freie Universität Berlin for the development of methods in NMR spectroscopy. He then worked at the Weizmann Institute in Rehovot, Israel and at the Sunnybrook Hospital, Toronto. Since 2003 he has led an interdisciplinary team of physicists, engineers, chemists, and physicians who have pioneered pivotal developments in time-harmonic elastography of both MRI and ultrasound for many medical applications.
Tobias Schaeffter is the head of divison of Medical Physics and metrological IT at the Physikalisch-Technische Bundesanstalt (PTB) in Berlin, Germany. He is also Professor in Imaging Sciences at the department of biomedical engineering at King's College London, UK. Tobias Schaeffter studied electrical engineering at TU-Berlin and did his PhD in magnetic resonance spectroscopic imaging (MRSI) under supervision of Prof. Leibfritz at University Bremen in 1996. From 1996-2006, he worked as a Principal Scientist at the Philips Research Laboratories in Hamburg, Germany, where he managed MR-research projects , their clinical evaluation and product integration. In April 2006, he took up the Philip Harris Professorship of Imaging Sciences at King's College London. In 2012 he became department head of biomedical engineering and was director of the doctorial training centre in medical imaging. Since 2015 he moved to PTB as a head of divison. A major aim of his research is the investigation of fast and quantitative MR-techniques for cardiovascular applications.
Ingolf Sack is a Heisenberg professor of the German Research Foundation for Experimental Radiology and Elastography at Charité-Universitätsmedizin Berlin, Germany. He received a PhD in Chemistry from Freie Universität Berlin for the development of methods in NMR spectroscopy. He then worked at the Weizmann Institute in Rehovot, Israel and at the Sunnybrook Hospital, Toronto. Since 2003 he has led an interdisciplinary team of physicists, engineers, chemists, and physicians who have pioneered pivotal developments in time-harmonic elastography of both MRI and ultrasound for many medical applications. Tobias Schaeffter is the head of divison of Medical Physics and metrological IT at the Physikalisch-Technische Bundesanstalt (PTB) in Berlin, Germany. He is also Professor in Imaging Sciences at the department of biomedical engineering at King’s College London, UK. Tobias Schaeffter studied electrical engineering at TU-Berlin and did his PhD in magnetic resonance spectroscopic imaging (MRSI) under supervision of Prof. Leibfritz at University Bremen in 1996. From 1996-2006, he worked as a Principal Scientist at the Philips Research Laboratories in Hamburg, Germany, where he managed MR-research projects , their clinical evaluation and product integration. In April 2006, he took up the Philip Harris Professorship of Imaging Sciences at King’s College London. In 2012 he became department head of biomedical engineering and was director of the doctorial training centre in medical imaging. Since 2015 he moved to PTB as a head of divison. A major aim of his research is the investigation of fast and quantitative MR-techniques for cardiovascular applications.
PART I: Tissue properties 1. Sack Multiscale biophysical interactions and parameters in medical imaging 2. Taupitz The Extracellular matrix as target for medical imaging 3. Käs Single cell physical properties and collective behavior in tumors. 4. Hirsch Biot's theory of biphasic poroelastic media and its application to incompressible tissue 5. Wall/Caiazzo Fluid dynamics in living systems PART II: Imaging technology & data analysis 6. Kutyniok Mathematical Methods in Medical Image Processing 7. Dewey, Kachelrieß Computed Tomography: Acquisition and Reconstruction 8. Tzschätzsch Ultrasound elastography methods 9. Buchert PET measured water perfusion 10. Abram Innovative radiotracers for PET 11. Schröder CEST-MRI 12. Schäffter/Kolbitsch Acceleration strategies for data sampling in MRI 13. Laufer Photoacoustic tomography PART III: Medical applications 14. Fischer, Thomas Tumor characterization by ultrasound perfusion measurements and elastography 15. Schmitter 4D flow quantification in cardiovascular MRI 16. Schäffter Cardiac perfusion MRI 17. Guo Noninvasive assessment of pressure-related imaging parameters in portal hypertension 18. Dewey, Kachelrieß Biophysical Parameters measured by dynamic computed tomography in the clinic 19. Brenner Quantification of functional heterogeneities in tumors by PET imaging 20. Niendorf Magnetic Resonance Myocardial Effective Transverse Relaxation Time at 7.0 Tesla for a Better Understanding of Myocardial (Patho)physiology.
Erscheint lt. Verlag | 21.2.2018 |
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Zusatzinfo | VIII, 497 p. 178 illus., 130 illus. in color. |
Verlagsort | Cham |
Sprache | englisch |
Themenwelt | Medizin / Pharmazie ► Medizinische Fachgebiete |
Naturwissenschaften ► Biologie | |
Schlagworte | Biophysical tissue properties • Biophysics-based medical imaging markers • Imaging biomarkers • Imaging Physics • imaging technology • Medical Image Processing • Medical technology • Parameter mapping • quantitative medical imaging |
ISBN-10 | 3-319-65924-3 / 3319659243 |
ISBN-13 | 978-3-319-65924-4 / 9783319659244 |
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