Channelopathies in Heart Disease -

Channelopathies in Heart Disease

Dierk Thomas, Carol Ann Remme (Herausgeber)

Buch | Hardcover
VI, 439 Seiten
2018 | 1st ed. 2018
Springer International Publishing (Verlag)
978-3-319-77811-2 (ISBN)
160,49 inkl. MwSt

This book provides an expert overview on ion channel-related arrhythmia mechanisms, and describes important advances in our understanding of how ion channel dysfunction causes cardiac disease. Both, scientific findings and clinical implications are presented and discussed by scientists who have considerably contributed to the field.

The book is organized in three parts: part I  treats the molecular and electrophysiological mechanisms of function and dysfunction of ion channels,  part II focuses on genetics and clinical findings, whereas part III describes novel research techniques, the use of stem cells and animal models and provides an outlook on future investigations and applications.

The book is written for scientists in Cardiovascular Biology and Neuroscience and will be of general interest to Medical Doctors in Cardiology, Cardiac Electrophysiology and related disciplines.

 

Prof. Dr. med. Dierk Thomas is Associate Professor at the University of Heidelberg and Head of the Cardiac Electrophysiology Department, Medical University Hospital, University of Heidelberg, Germany. Dr. Carol Ann Remme is Associate Professor and Principal Investigator at the Department of Clinical and Experimental Cardiology, Academic Medical Center, Amsterdam, The Netherlands.

Introduction.- Part 1: (Dys)function of cardiac ion channels. Cardiac sodium channel (dys)function and inherited arrhythmia syndromes.- Potassium channels in the heart.- Voltage-gated calcium channels and their roles in cardiac electrophysiology.-  HCN channels and cardiac pacemaking.- Dysregulation of ionic homeostasis: relevance for cardiac arrhythmias.- Part 2: Cardiac channelopathies: clinical and genetic findings. Long and short QT syndromes.- Brugada syndrome: current perspectives.- Sinus node disease and cardiac conduction disease.- Catecholaminergic polymorphic ventricular tachycardia.- Idiopathic ventricular fibrillation and early repolarization.- Atrial fibrillation.- Genetic testing for inheritable cardiac channelopathies.- Part 3: Research into cardiac channelopathies: new avenues. Novel imaging techniques in cardiac ion channel research.- Transgenic animal models of cardiac channelopathies - benefits and limitations.- Induced pluripotent stem cell-derived cardiomyocytes: towards personalized therapeutic strategies?.  

Erscheinungsdatum
Reihe/Serie Cardiac and Vascular Biology
Zusatzinfo VI, 439 p. 73 illus., 58 illus. in color.
Verlagsort Cham
Sprache englisch
Maße 155 x 235 mm
Gewicht 822 g
Themenwelt Medizin / Pharmazie Physiotherapie / Ergotherapie Orthopädie
Medizin / Pharmazie Studium
Naturwissenschaften Biologie Genetik / Molekularbiologie
Technik Umwelttechnik / Biotechnologie
Schlagworte Animal Models • cardiac arrhythmias • cardiac disease • cardiomyocytes • Channelopathies • Computational modeling • electrophysiology • heart • induced pluripotent stem cells • ion channels • IPSC
ISBN-10 3-319-77811-0 / 3319778110
ISBN-13 978-3-319-77811-2 / 9783319778112
Zustand Neuware
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