Channelopathies in Heart Disease (eBook)

Prof. Dr. med. Dierk Thomas is Associate Professor at the University of Heidelberg and Head of the Cardiac Electrophysiology Department, Medical University Hospital, University of Heidelberg, Germany. Dr. Carol Ann Remme is Associate Professor and Principal Investigator at the Department of Clinical and Experimental Cardiology, Academic Medical Center, Amsterdam, The Netherlands.

Part A: (Dys)function of cardiac ion channels   2. The electrophysiological basis of cardiac conduction and repolarization (include also: Distribution of ion channels in the heart (atrium vs ventricle, conduction system versus working myocardium, Purkinje, transmural distribution)) Jules Hancox (University of Bristol, UK; Jules.Hancox@bristol.ac.uk)   3.  Novel insights into ion channel complexity and diversity: relevance for cardiac  channelopathies (interacting proteins, subcellular distribution, non-electrogenic effects, electro-mechanical overlap, impact on other organs, etc).                       Hugues Abriel (Bern, CH)   4. Cardiac sodium channel structure and (dys)function                                                 C.A. Remme (Amsterdam, NL)   5. Potassium channels in the heart: structure and (dys)function                                     Nicole Schmitt (Copenhagen, Denmark; nschmitt@sund.ku.dk)   6. Calcium channels and their roles in cardiac electrophysiology                                               Niels Voigt (Göttingen; Germany; niels-voigt@t-online.de)   7. HCN channels and cardiac pacemaking Mirko Baruscotti (Department of Biomolecular Sciences and Biotechnology, University of Milan, Italy; mirko.baruscotti@unimi.it)   8. (Dys)regulation of ionic homeostasis: relevance for cardiac arrhythmias (including ryanodine receptor channelopathies, etc)                                                                       Luigi Venetucci (Institute of Cardiovascular Sciences, University of Manchester, UK; luigi.venetucci@manchester.ac.uk)     Part B: Cardiac channelopathies: clinical and genetic findings   9. Long QT syndrome (including Timothy syndrome), short QT syndrome                       Lia Crotti (Department of Molecular Medicine, University of Pavia, Pavia, Italy; liacrotti@yahoo.it)             10. Brugada syndrome                                                                                    Koonlawee Nademanee (The Pacific Rim Electrophysiology Research Institute, Los Angeles, USA; wee@pacificrimep.com)   11. Sinus node disease and Lev-Lenègre syndrome-progressive cardiac conduction disease Patrick Schweizer (Heidelberg, Germany; patrick.schweizer@med.uni-heidelberg.de)   12. Catecholaminergic polymorphic ventricular tachycardia                                           Bjorn C. Knollmann (Vanderbilt University School of Medicine, Nashville, USA; bjorn.knollmann@vanderbilt.edu)   13. Idiopathic ventricular fibrillation and early repolarization                                           Pieter Postema (Academic Medical Center, Amsterdam, The Netherlands; p.g.postema@amc.uva.nl)   14. Atrial fibrillation       Dierk Thomas (Heidelberg, Germany)                                                                                     15. Pulmonary arterial hypertension                   Horst Olschewski (Ludwig Boltzmann Institute for Lung Vascular Research, Medical University of Graz, Austria; horst.olschewski@medunigraz.at)   16. Genetic testing for inheritable cardiac channelopathies                                Julien Barc (l'institut du thorax, Nantes, France; julien.barc@inserm.fr)     Part C: Research into cardiac channelopathies: new avenues   17. Novel imaging techniques in cardiac ion channel research                           Eli Rothenberg (Department of Biochemistry and Molecular Pharmacology, New York, USA; Eli.Rothenberg@nyumc.org)   18. iPSC-CM: towards personalized therapeutic strategies?                               Alessandra Moretti (Technical University of Munich, Germany; amoretti@mytum.de)             19. Computational modeling in cardiac channelopathy research Blanca Rodriguez (Department of Computer Science, University of Oxford, Oxford, UK; blanca.rodriguez@cs.ox.ac.uk)   20. Identification of disease modifiers in cardiac channelopathies Elisabeth Lodder/Connie Bezzina (Academic Medical Center, Amsterdam, The Netherlands; e.m.lodder@amc.uva.nl)   21. Transgenic animal models of cardiac channelopathies – benefits and limitations Katja Odening (Universitäts-Herzzentrum Freiburg, Germany; katja.odening@uniklinik-freiburg.de)