Neurodegeneration (eBook)

Danilo Milardi obtained a degree in Industrial Chemistry from the University of Catania before going on to obtain a PhD in protein thermodynamics. He has been involved in various MIUR projects concerned with protein thermodynamics and in 1997 obtained a fellowship of the University of Catania in collaboration with Cyanamid S.p.A. He currently works as research scientist at the Italian Consiglio Nazionale delle Ricerche (CNR) - Instituto di Biostrutture e Bioimmagini. He also has extensive experience in teaching and the coordination of research projects. Dr Milardi was a member of the organizing committee of the 8th National Meeting of the Italian Liquid Crystal Society and is the author of 41 scholarly papers and 60 communications to national and international congresses. Enrico Rizzarelli is currently a professor in the Dipartimento di Scienze Chimiche at the UniversitÓ di Catania. His main research Interests include: molecular recognition processes assisted by metal ions; synthesis, characterization and biological activity of copper(II) coordination compounds; protein misfolding diseases and metal ions, and model systems of metal enzymes with antioxidant activities. He is a member of numerous scholarly societies and has been an invited speaker or chair at many national and international meetings. He regularly referees manuscripts for numerous international journals and has authored about 220 papers himself. He has co-authored and guest edited several key books and been the author of three European patents. Enrico Rizzarelli also refereed research projects on the behalf of Italian and international research bodies.

Chemical evolution, brain and metallomics Chemistry and biology of proteostasis Environmental factors affecting cellular proteostasis Neurodegeneration and cell membranes The role of Metals in the intracellular clearance of amyloids Speciation, coordination sites and metal binding affinities of proteins related to neurodegeneration Copper, Zinc and trophic factors in neurodegeneration Metals as catalysts of ROS production in neurodegeneration Metal hypothesis of Alzheimer disease Copper supply and metal homeostasis in AD The role of iron in neurodegeneration Aluminium in neurodegenerative diseases Zinc trafficking in the AD brain The role of metal ions in the pathogenesis of Parkinson's disease Metals in ALS pathology Metals and prion diseases