Mouse Models for Drug Discovery

Improving Toxicity Screening and Drug Development by Using Genetically Defined Strains.- The Sophisticated Mouse: Protecting a Precious Reagent.- Genetically Engineered Mouse Models in Drug Discovery Research.- Engineering the Mouse Genome to Model Human Disease for Drug Discovery.- Profiling of Drug Action Using Reporter Mice and Molecular Imaging.- Human FcRn Transgenic Mice for Pharmacokinetic Evaluation of Therapeutic Antibodies.- Development of Novel Major Histocompatibility Complex Class I and Class II-Deficient NOD-SCID IL2R Gamma Chain Knockout Mice for Modeling Human Xenogeneic Graft-Versus-Host Disease.- Bridging Mice to Men: Using HLA Transgenic Mice to Enhance the Future Prediction and Prevention of Autoimmune Type 1 Diabetes in Humans.- Mouse Models of Type II Diabetes Mellitus in Drug Discovery.- Cholesterol Absorption and Metabolism.- Collagen-Induced Arthritis in Mice.- Skin Diseases in Laboratory Mice: Approaches to Drug Target Identification and Efficacy Screening.- Models of Metastasis in Drug Discovery.- Methods for Evaluating Effects of an Irinotecan + 5-Fluorouracil/Leucovorin (IFL) Regimen in an Orthotopic Metastatic Colorectal Cancer Model Utilizing In Vivo Bioluminescence Imaging.- CML Mouse Model in Translational Research.- Mouse Models for Studying Depression-Like States and Antidepressant Drugs.- Virus-Delivered RNA Interference in Mouse Brain to Study Addiction-Related Behaviors.- Experimental Models of Anxiety for Drug Discovery and Brain Research.- Mouse Models of Neurodegenerative Diseases: Criteria and General Methodology.- Neuromuscular Disease Models and Analysis.- Murine Model of Cutaneous Infection with Streptococcus pyogenes.- Murine Model of Pneumococcal Pneumonia.- Murine Model of Polymicrobial Septic Peritonitis Using Cecal Ligation and Puncture (CLP).- Erratum to: Human FcRn Transgenic Mice for Pharmacokinetic Evaluation of Therapeutic Antibodies.