Neuropsychiatric Disorders and Epigenetics (eBook)

Dennis R. Grayson, Jacob Peedicayil (Herausgeber)

eBook Download: PDF | EPUB

2016 | 1. Auflage
444 Seiten
Elsevier Science (Verlag)
978-0-12-800527-9 (ISBN)

Neurobehavioral Disorders and Epigenetics is a comprehensive reference for the epigenetic basis of most common neurobehavioral disorders. The volume is organized into 22 chapters representing individual neurological disorders, from Addiction to Stress. The epigenetic aspects of each disorder are addressed by at least two scientists with expertise in that research area. Particular emphasis is placed by each contributing author on potential epigenetic interventions. In an effort to cover a broad range of epigenetic mechanisms including DNA modification, histone post-translational modification, chromatin organization and non-coding RNA, author contributions were selected accordingly. In addition the effects of environmental stimuli on epigenetic states is addressed in some chapters based on relevance to disease induction.

Recent discoveries in epigenetic research enabled by advances in genomic technologies, have positioned the field for broad translation to therapeutic interventions for previously unmanageable disorders. Clearly neurobehavioral disorders represent a prime target of epigenetic interventions as they are highly debilitating, often chronic diseases with high costs to society. Thus, these collected works will define epigenetics as a key player in neurobehavioral disorders, highlight the full spectrum of epigenetic mechanisms underlying such disorders and introduce the vast range of epigenetic therapies under development.

Relates the effects of environmental stimuli on epigenetic states to neurological disease induction
Analysis of the epigenetic basis for common neuropsychiatric disorders and how it guides treatment, providing insight and perspective to both clinicians and basic scientists
Extensive use of diagrams, illustrations and tables, and graphical abstracts for each subsection permits rapid review

Neuropsychiatric Disorders and Epigenetics is a comprehensive reference for the epigenetic basis of most common neuropsychiatric disorders. The volume is organized into chapters representing individual neuropsychiatric disorders, from addition to obesity contributed by leading experts in their respective fields. The epigenetic aspects of each disorder are discussed, in the context of the full range of epigenetic mechanisms including DNA modification, histone post-translational modification, chromatin organization and non-coding RNA. A particular emphasis is placed on potential epigenetic interventions, when the effects of environmental stimuli on epigenetic states is particularly relevant o disease. Recent discoveries in epigenetic research enabled by epic advances in genomic technologies have positioned the field for broad translation to therapeutic interventions for previously unmanageable disorders Neuropsychiatric disorders represent a prime target of epigenetic interventions as they are highly debilitating, often chronic diseases with enormous costs to society. Thus, this volume will help define epigenetics as a key player in neuropsychiatric disorders, highlighting the full spectrum of epigenetic mechanisms underlying such disorders and introducing the vast range of epigenetic therapies under development. Analyzes the effects of environmental stimuli on epigenetic states that correlate with neuropsychiatric disease induction Reviews the epigenetic basis for common neuropsychiatric disorders, thereby guiding translational therapies for clinicians and mechanistic studies for scientists Extensive use of diagrams, illustrations, tables, and graphical abstracts for each section providing rapid assessment

Erscheint lt. Verlag	15.11.2016
Sprache	englisch
Themenwelt	Geisteswissenschaften ► Psychologie ► Biopsychologie / Neurowissenschaften
	Medizin / Pharmazie ► Medizinische Fachgebiete ► Neurologie
	Naturwissenschaften ► Biologie ► Genetik / Molekularbiologie
ISBN-10	0-12-800527-0 / 0128005270
ISBN-13	978-0-12-800527-9 / 9780128005279

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Andere Ausgabe

Buch | Hardcover (2016)

103,50 €