The Decade of Autoimmunity

Prof. Yehuda Shoenfeld is the founder and head of the Zabludowicz Center for Autoimmune Diseases, at the Sheba Medical Center which is affiliated to the Sackler Faculty of Medicine in Tel-Aviv University, in Israel. Dr. Shoenfeld is the Incumbent of the Laura Schwarz-Kipp Chair for Research of Autoimmune Diseases at the Tel-Aviv University. His clinical and scientific works focus on autoimmune and rheumatic diseases, and he has published more than 1750 papers in journals such as New Eng J Med, Nature, Lancet, Proc Nat Acad Scie, J Clin Invest, J Immunol, Blood, FASEB, J Exp Med, Circulation, Cancer and others. His articles have had over 35,000 citations. He has written more than three hundred and fifty chapters in books, and has authored and edited 25 books, some of which became cornerstones in science and clinical practice, such as "The Mosaic of Autoimmunity", "Infections and Autoimmunity" and the textbook "Autoantibodies" and "Diagnostic criteria of autoimmune diseases", all of which were published by Elsevier and sold by the thousands. He is on the editorial board of 43 journals in the field of rheumatology and autoimmunity and is the founder and the editor of the IMAJ (Israel Medical Association Journal) the representative journal of science and medicine in the English language in Israel, and also is the founder and Editor of the "Autoimmunity Reviews" (Elsevier) (Impact factor 7.9) and Co-Editor of "Journal of Autoimmunity" (Impact factor 8.1). He has organized over 20 international congresses in autoimmunity. Prof. Shoenfeld received the EULAR prize in 2005, in Vienna, Austria: "The infectious etiology of anti-phospholipid syndrome". He has received a gold medal from the Slovak Society of Physicians for his contribution to Israel – Slovakia collaboration (March 2006), and is honorary member of the Hungarian Association of Rheumatology. In UC Davis, USA, Dr. Shoenfeld received the Nelson's Prize for Humanity and Science for 2008. In 2009 he was honored as Doctoris Honoris Causa, from Debrecen University (Hungary), and from 2009 he is honorary member of the Slovenian National Academy of Sciences. He has recently been awarded a Life Contribution Prize in Internal Medicine in Israel, 2012 as well as the ACR Master Award in 2013. Prof. Shoenfeld has educated a long list of students (>25) being heads of departments and institutes.

Introduction: The Decade of Autoimunity. 1. The mystery of autoimmune diseases. 2. Innovations in Autoimmunity in the last decade. 3. Thyroiditis and Myocarditis - A tale of two diseases. 4. Autoimmune Thyroid Disease: An expanding spectrum of antibodies to the thyrotropin receptor. 5. The antigens of PBC: Who are they and where do they come from. 6. The search for an animal model for Graves' Disease. 7. Hughes Syndrome: A short history of Antiphopholipid Syndrome (G.R.V. Hughes, M.A. Khamashta). 8. Anticardiolipin antibody, thrombosis and atherosclerosis. 9. B2-glycoprotein I and the Antiphospholipid Syndrome: In vitro and in vivo studies. 10. Clinical associations of antibodies to phospholipids and/or their protein cofactors. 11. Perspectives on Systemic Lupus Erythematosus (SLE) - A model for autoimmunity. 12. Pathogenic aspects of Systemic Lupus Erythematosus. 13. Immunomodulation of experimental antiphospholipid syndrome: Lessons from murine models. 14. Experimental Systemic Lupus Erythematosus: From a pathogenic antibody to immunomodulating proteins. 15. What does the Wolf in Lupus bite? Reflections on the nature of the target antigen in SLE. 16 Brain, Behaviour and Lupus. 17. Sjögren's Syndrome: The significance of epithelial cells. 18. SSA/Ro and SSB/La autoantigens, their corresponding antibodies and their clinical relevance. 19. The immunology of diabetes: revolution of concepts over a decade. 20. The pathogenesis and clinical relevance of Heparin-Indiced Autoantibodies. 21. Experimental autoimmune encephalomyelitis induced by various antigens of the central nervous system. Overview and relevance to Multiple Sclerosis. 22. Immunosuppressive and immunomodulating therapeutic approaches for induction of self-tolerance in experimental autoimmune encephalo-myelitis (EAE and CR-EAE) and multiple sclerosis (MS). 23. Development of copolymer 1 (Copaxone®) as a specific drug against multiple sclerosis. 24. Pemphigus, an autoimmune disease of the