Decade of Autoimmunity (eBook)
431 Seiten
Elsevier Science (Verlag)
978-0-08-053030-7 (ISBN)
A variety of different subjects in autoimmunity, from etiology to pathogenesis, from postulated mechanisms to innovative therapeutic modalities, is handled by noted contributors, while additional authors contribute top papers which significantly enhance a better understanding of autoimmunity.
An excellent treatise on the subject, and a worthwhile addition to both clinical and research libraries.
This book is a direct result of 10 years of the well-known "e;Autoimmunity Days"e; in Israel, which are increasingly becoming an international focal point for autoimmunity scientists. Top researchers provide coverage of the most important knowledge generated during the last decade. The volume can therefore be seen almost as a textbook on autoimmunity, projecting from the last decade to the next millennium. A variety of different subjects in autoimmunity, from etiology to pathogenesis, from postulated mechanisms to innovative therapeutic modalities, is handled by noted contributors, while additional authors contribute top papers which significantly enhance a better understanding of autoimmunity. An excellent treatise on the subject, and a worthwhile addition to both clinical and research libraries.
Front Cover 1
The Decade of Autoimmunity 3
Copyright Page 4
Contents 16
The Decade of Autoimmunity 6
List of Contributors 8
Chapter 1. The Mystery of Autoimmune Diseases 20
Chapter 2. Innovations in Autoimmunity in the Last Decade 26
Section I: Thyroid disease 26
Chapter 3. Thyroiditis and Myocarditis: A Tale of Two Diseases 38
Chapter 4. Autoimmune Thyroid Disease: an Expanding Spectrum of Antibodies to the Thyrotropin Receptor 44
Section II: PBC 50
Chapter 5. The Antigens of Primary Biliary Cirrhosis: Who Are They and Where Do They Come From? 50
Chapter 6. The Search for an Animal Model for Graves' Disease 62
Section III: Antiphospholid syndrome 70
Chapter 7. Hughes Syndrome: A Short History of Antiphospholipid Syndrome 70
Chapter 8. Anticardiolipin Antibody, Thrombosis and Atherosclerosis 76
Chapter 9. B2-Glycoprotein I and the Antiphospholipid Syndrome: In Vitro and In Vivo Studies 86
Chapter 10. Clinical Associations of Antibodies to Phospholipids and/or Their Protein Cofactor 94
Chapter 11. Immunomodulation of Experimental Antiphospholipid Syndrome: Lessons from Murine Models 114
Section IV: SLE 100
Chapter 12. Perspectives on Systemic Lupus Erythematosus (SLE): A Model for Autoimmunity 100
Chapter 13. Pathogenic Aspects of Systemic Lupus Erythematosus 104
Chapter 14. Experimental Systemic Lupus Erythematosus: From a Pathogenic Autoantibody to Immunomodulating Peptides 128
Chapter 15. What Does the Wolf in Lupus Bite?: Reflections on the nature of the target antigen in SLE 138
Chapter 16. Brain, Behaviour and Lupus 146
Section V: Sjögren's syndrome 154
Chapter 17. Sjögren's Syndrome: The significance of epithelial cells 154
Chapter 18. SSA/Ro and SSB/La Autoantigens, Their Corresponding Antibodies and Their Chnical Relevance 162
Section VI: Diabetes 168
Chapter 19. The Immunology of Diabetes: Revolution of Concepts Over a Decade 168
Section VII: HIT 176
Chapter 20. The Pathogenesis and Clinical Relevance of Heparin-Induced Autoantibodies 176
Section VIII: EAE 188
Chapter 21. Experimental Autoimmune Encephalomyelitis Induced by Various Antigens of the Central Nervous System: Overview and Relevance to Multiple Sclerosis 188
Chapter 22. Immunosuppressive and Immunomodulating Therapeutic Approaches for Induction of Self-Tolerance in Experimental Autoimmune Encephalomyelitis (EAE and CR-EAE) and Multiple Sclerosis 198
Chapter 23. Development of Copolymer 1 (Copaxone®) as a Specific Drug Against Multiple Sclerosis 210
Section IX: Pemphigus 216
Chapter 24. Pemphigus an Autoimmune Disease of the Skin: Cell-Cell Separation Versus Membranal Signaling and Apoptosis in Acantholysis 216
Section X: Scleroderma 228
Chapter 25. What Can We Learn From an Avian Model for Scleroderma? 228
Section XI: ANCA 238
Chapter 26. Antineutrophil Cytoplasmic Autoantibodies in Vasculitis: From Recognition to Diagnostic Tool 238
Chapter 27. Are Antineutrophil Cytoplasmic Antibodies Pathogenic in Wegener's Granulomatosis? Lessons From In Vitro and In Vivo Experimental Findings 246
Section XII: Cryoglobulinemia 254
Chapter 28. From Essential Mixed Cryoglobulinemia to Virus-induced Autoimmunity: Ten Years of Research on Mixed Cryoglobulinemia 254
Section XIII: Myasthenia 264
Chapter 29. The Involvement of Myasthenogenic T-cell Epitopes and Their Analogs in the Clinical Manifestations and Treatment of Myasthenia Gravis 264
Chapter 30. Antigen-Specific Immunomodulation of Experimental Autoimmune Myasthenia Gravis 274
Section XIV: Vitiligo 280
Chapter 31. A Focus on Anti-Tyrosinase Antibodies in Melanoma and Vitiligo 280
Section XV: Celiac 288
Chapter 32. Celiac Disease—An Autoimmune Entity? 288
Section XVI: New Autoantibodies 296
Chapter 33. Autoimmunity Against Platelets in Schizophrenia 296
Chapter 34. Antiendothelial Cell Antibodies (AECA): From a Laboratory Curiosity to Another Useful Autoantibody 304
Section XVII: Cellscan 304
Chapter 35. Detection of Cellular Activity in Autoimmune Disorders by the Cellscan System 314
Section XVIII: Basic 324
Chapter 36. Dominance, Crypticity and Autoimmune Disease 324
Section XIX: Cytokines 332
Chapter 37. Cytokines in Autoimmunity 332
Chapter 38. Tumor Necrosis Factor in Rheumatoid Arthritis and SLE 342
Section XX: Hormones 352
Chapter 39. Effects of Sex Hormones on Immune Responses and Autoimmune Diseases: An Update 352
Chapter 40. Prolactin and Autoimmunity 358
Section XXI: Oncogenes 366
Chapter 41. The Role of Proto-Oncogenes in Autoimmunity 366
Chapter 42. Hepatitis C Virus and Autoimmunity 374
Chapter 43. T-Cell Migration Through Cytokine-Associated Extracellular Matrices to Inflammatory Sites 384
Section XXII: Complement 390
Chapter 44. Defective Handling of Complement and Its Possible Role in Intravascular Inflammation in the Elderly and in the Sequestration of Erythrocytes 390
Section XXIII: CD5 398
Chapter 45. CD5-Positive B Cells in Tolerance and Autoimmunity 398
Section XXIV: BM 418
Chapter 46. Autologous and Allogenic Stem Cell Transplantation for the Treatment of Autoimmune Diseases as a Potential New Approach for the Treatment of Immune Diseases 418
Section XXV: IVIG 428
Chapter 47. Immunomodulation of Autoimmune Disease with Normal Polyspecific Immunoglobulin G (Intravenous Immunoglobulin) 428
Subject Index 440
List of Contributors
Oded Abramsky Department of Neurology, Hadassah Medical Center, Hebrew University Hospital, Ein Kerem, Jerusalem, IL-91120, Israel
Mahmoud Abu-Shakra Rheumatic Disease Unit, Soroka Medical Center and Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer Sheva, Israel
Dan Aderka Oncology Department, Ichilov Medical Center, Tel Aviv 64239, Israel
Rina Aharoni Department of Immunology, Weizmann Institute of Science, Rehovot 76100, Israel
S. Ansar Ahmed Virginia Tech, Department of Biomedical Sciences and Pathology, Virginia-Maryland Regional College of Veterinary Medicine, Phase 11 Duck Pond Drive, Blacksburg, VA 24061-0442, USA
Donato Alarcón-Segovia Department of Immunology and Rheumatology, Institute National de la Nutrición, Salvador Zubirán, Vasco de Quiroga 15, Delagacion Thalpan, CP 14000 Mexico City, Mexico
Micha Amit Department of Internal Medicine “B”, Assaf Harofeh Medical Center, Zerifin 70300, Israel
Gowthami Arepally Department of Pathology, UNM School of Medicine, 915 Camino de Salud, NE, Albuquerque, NM 87131-5301, USA
Ruth Arnon Department of Immunology, The Weizmann Institute of Science, P.O. Box 26, Rehovot 76100, Israel
Jean-François Bach Immunology Clinique, Hôpital Necker, 161 Rue de Sevres, 75743 Paris Cedex 15, France
Genesio Balestrieri Servizio di Immunologia e Allergologia Clinica, Spedali Civili di Brescia-University of Brescia, 25123 Brescia, Italy
Vivian Barak Cancer Immunology Institute, Hadassa Medical Center, Ein Kerem, Jerusalem 91120, Israel
Eldad Ben-Chetrit Department of Internal Medicine A’, Hadassa Medical Center, Ein Kerem, Jerusalem 91120, Israel
Avraham Ben-Nun Department of Immunology, The Weizmann Institute of Science, P.O. Box 26, Rehovot 76100, Israel
Miri Blank Laboratory of Autoimmune Diseases, Sheba Medical Center, Tel-Hashomer 52621, Israel
Stefano Bombardieri Istituto di Patologia Medica, Metodologia Clinica dell’Universita Di Pisa, Via S. Maria 31, 56100 Pisa, Italy
François Brégégère Myers Skin Biochemistry Unit, The Department of Biological Chemistry, Life Sciences Institute, The Hebrew University Givat-Ram, Jerusalem 91904, Israel
Dan Buskila Department of Internal Medicine B’, Soroka Medical Center, P.O. Box 151, Beer Sheva 84101, Israel
Antonio R. Cabral Instituto Nacional de la Nutrición, Salvador Zubirán, Vasco de Quiroga 15, Delagacion Tlalpan, CP 14000 Mexico City, Mexico
Ramona M. Carbotte Department of Psychiatry, McMaster University, Hamilton, ON L8N 3Z5, Canada
Ricard Cervera Medicina Interna, Malaties Autoimmunes, Serveide Medicina Interna General, Hospital Clinic, Villaroel 170, 08036 Barcelona, Spain
Douglas B. Ones Hospital of the University of Pennsylvania, Philadelphia, PA 19072, USA
Irun R. Cohen Department of Immunology, Weizmann Institute of Science, Rehovot, 76100, Israel
J.W. Cohen Tervaert Department of Clinical Immunology, University Hospital Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands
Ross L. Coppel Department of Microbiology, Monash University, Clayton, VIC 3168, Australia
Terry F. Davies Mount Sinai Medical Center, One Gustav L. Levy Place, New York, NY 10029-6574, USA
M. Deckmann Department of Biological Chemistry, The Weizmann Institute of Science, Rehovot 76100, Israel
Nicoletta Del Papa Istituto di Medicina Interna, Malattie Infettive e Immunopatologia, IRCCS Policlinico, University of Milan, Via F. Sforza 35, 20122 Milan, Italy
A. Della Rossa Clinical Immunology and Rheumatology Unit, Istituto di Patologia Medica, University of Pisa, 56100 Pisa, Italy
Judah A. Denburg McMaster University, Division of Clinical Immunology & Allergy, Room 3 V46, Hamilton, ON, Canada L5N 3Z5
Susan D. Denburg Department of Psychiatry, McMaster University, Hamilton, ON L8N 3Z5, Canada
Moti Deutsch Schottenstein Cellscan Center, Physics Department, Bar Ilan University, Ramat Gan, Israel
Michael Ehrenfeld Department of Medicine “D”, Sheba Medical Center, Tel Hashomer, Israel
T.E.W. Feltkamp Arthron, Jan van Breemenstr. 2, 1056 AB Amsterdam, The Netherlands
C. Ferri Clinical Immunology and Rheumatology Unit, Istituto di Patologia Medica, University of Pisa, 56100 Pisa, Italy
Maora Finemesser Department of Pathology, The Rabin Medical Centre Belinson Hospital, Pertach-Tikva, Israel
Pnina Fishman Mor Yisum, Ben Gurion St. 11, Givat Shmuel 54013, Israel
Suzanne Franitza The Department of Immunology, The Weizmann Institute of Science, Rehovot 76100, Israel
Masha Fridkis-Hareli Department of Immunology, The Weizmann Institute of Science, P.O. Box 26, Rehovot 76100, Israel
Sara Fuchs Department of Immunology, The Weizmann Institute of Science, P.O. Box 26, Rehovot 76100, Israel
Sunadar Gerbat Medis-El Ltd, P.O. Box 45031, Jerusalem 91450, Israel
Harriet Gershon Rappaport Institute, Rainbam Medical Center, Haifa 31096, Israel
M. Eric Gershwin Division of Rheumatology, Allergy and Clinical Immunology, School of Medicine-TB 192, University of California at Davis, Davis, CA, 95616-8660, USA
P. Heeringa Department of Clinical Immunology, University Hospital Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands
M. Hermann Department of Internal Medicine III and, Institute for Clinical Immunology und, Rheumatology, University of Erlangen-Nürnberg, Krankenhausstrasse 12
Graham R.V. Hughes Department of Rheumatology, St Thomas’ Hospital, Lambeth Palace Road, London SE1 7EH, UK
C. Jamin University of Brest, Postbox 824, 29609 Brest, France
Joachim R. Kalden Medizinische Klinik III, Der Friedrich Alexander Universitat, Krankenhausstrasse 12, 91054 Erlangen, Germany
Cees G.M. Kallenberg Department of Clinical Immunology, University Hospital Groningen, Hanzeplein 1, 9713 EZ Groningen, The Netherlands
Demitrius Karussis Department of Neurology, Hadassa Medical Center, Ein Kerem, Jerusalem 91120, Israel
Srini V. Kaveri INSERM U430 and Université Pierre et Marie, Curie, Hôpital Broussais, Paris, France
M. Kaufman Schottenstein Cellscan Center, Physics Department, Bar Ilan University, Ramat Gan, Israel
Michel D. Kazatchkine INSERM Unité 430, Immunopathologie Humaine, Hôpital Broussais, 96 Rue Didot, 75014 Paris Cedex 14,...
| Erscheint lt. Verlag | 15.2.1999 |
|---|---|
| Sprache | englisch |
| Themenwelt | Medizin / Pharmazie ► Medizinische Fachgebiete ► Dermatologie |
| Studium ► Querschnittsbereiche ► Infektiologie / Immunologie | |
| Naturwissenschaften ► Biologie ► Zellbiologie | |
| ISBN-10 | 0-08-053030-3 / 0080530303 |
| ISBN-13 | 978-0-08-053030-7 / 9780080530307 |
| Haben Sie eine Frage zum Produkt? |
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