Asymmetric Synthesis of Non-Proteinogenic Amino Acids (eBook)

Ashot Saghyan is Director of the Scientific and Production Center "Armbiotechnology" of the National Academy of Sciences of the Republic of Armenia. In 1985, he accomplished his post-graduate studies under the supervision of Prof. Yu. N. Belokon' at the A.N. Nesmeyanov Institute of Organoelement Compounds of the Academy of Sciences of the Soviet Union. In 1997, he defended his doctoral thesis. He has been working for the Institute of Biotechnology first as a researcher, head of the Laboratory of Asymmetric Synthesis and since 2000 as director. At the same time he is head of the Pharmaceutical Chemistry Department of Yerevan State University (since 2003). In 2006, he was elected Corresponding Member and, in 2010, Full Member of the National Academy of Sciences of the Republic of Armenia. Saghyan has authored over 400 scientific publications and has received a number of scientific awards, e.g. European R. Descartes Prize. He is a long-term editor-in-chief of the Chemical Journal of Armenia. Peter Langer studied chemistry at the University of Hannover and at the Massachusetts Institute of Technology (MIT, USA). In February 1997 he obtained his Dr. rer. nat. at the University of Hannover. During a postdoctoral period in Cambridge (UK) he worked on the synthesis of oligosaccharides. In 1998 he moved to the University of Göttingen where he completed his habilitation in July 2001. In April 2002 he took a permanent position as a full professor (C4) at the University of Greifswald. In December 2004 Peter Langer moved to a new position as a full professor (C4) at the University of Rostock. Since July 2005 he is also affiliated to the Leibniz-Institute of Catalysis e. V. at the University of Rostock (LIKAT) as the head of the division `organic synthesis'. Prof. Langer is coauthor of more than 600 research papers and reviews. His research is focused on the development of new synthetic methods and their application to the synthesis of biologically relevant ring systems. Professor Langer received several prestigious scholarships (Studienstiftung des Deutschen Volkes, Feodor-Lynen-scholarship, Liebig scholarship, Heisenberg-scholarship), international awards, and honorary doctorates of several universities. In 2015 Peter Langer has been elected foreign member of the National Academy of Science of Armenia.

Introduction

1. NON-PROTEIN ALPHA-AMINO ACIDS, ASPECTS OF THEIR APPLICATION
1.1. Natural Origin, Biological Functions
1.2. Amino Acids as Radiopharmaceuticals in PET Diagnostics

2. NATURAL SYNTHESIS OF AMINO ACIDS, MECHANISMS AND MODELING
2.1. Regularity of Mechanisms for the Natural Synthesis of Amino Acids
2.2. Systems for Modeling Some Aspects of Pyridoxal Enzyme Action
2.3. Modeling of Processes Associated with Cleavage of C-alpha-H and C-alpha-C-beta Bonds
2.4. Modelling of alpha. beta-Elimination Processes of PP-Catalysis, Kinetics and Stereochemistry
2.5. Biomimetic Addition Reaction of Nucleophiles to Co(III) Complexes Of Dehydroaminobutyric Acid

3. ASYMMETRIC SYNTHESIS OF NON-PROTEIN ALPHA-AMINO ACIDS
3.1. The Main Rules of Asymmetric Synthesis
3.2. Catalytic Asymmetric Synthesis
3.3. Stoichiometric Asymmetric Synthesis of Alpha-Amino Acids