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Cellular Ageing and Replicative Senescence (eBook)

Suresh I.S. Rattan, Leonard Hayflick (Herausgeber)

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2016 | 1st ed. 2016
VIII, 364 Seiten
Springer International Publishing (Verlag)
978-3-319-26239-0 (ISBN)

Lese- und Medienproben

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This book covers the origins and subsequent history of research results in which attempts have been made to clarify issues related to cellular ageing, senescence, and age-related pathologies including cancer. Cellular Ageing and Replicative Senescence revisits more than fifty-five years of research based on the discovery that cultured normal cells are mortal and the interpretation that this phenomenon is associated with the origins of ageing. The mortality of normal cells and the immortality of cancer cells were also reported to have in vivo counterparts. Thus began the field of cytogerontology.

Cellular Ageing and Replicative Senescence is organized into five sections: history and origins; serial passaging and progressive ageing; cell cycle arrest and senescence; system modulation; and recapitulation and future expectations. These issues are discussed by leading thinkers and researchers in biogerontology and cytogerontology. This collection of articles provides state-of-the-art information, and will encourage students, teachers, health care professionals and others interested in the biology of ageing to explore the fascinating and challenging question of why and how our cells age, and what can and cannot be done about it.

Preface Section I History and originsChapter 1: Origins of the Hayflick system, the phenomenon and the limit. (an interview by Suresh I.S. Rattan) Chapter 2: Experimental foundations of the Hayflick system. (an interview by Suresh I.S. Rattan) Section II Serial passaging and progressive changesChapter 3: Slowing down of the cell cycle during fibroblast proliferation. by: Alvaro Macieira-Coelho Chapter 4: Influence of donor age and species longevity on replicative cellular senescence. by: Lorenzini and Andrea B. Maier Chapter 5: Ageing of the stem cells: the conjoined twosome growing old –stem cell and its niche. by: Günter Lepperdinger Chapter 6: Ageing and senescence in immune cells in vitro and in vivo. by: Graham Pawelec and Yvonne Barnett Chapter 7: Telomere shortening – a mere replicometer? by: Stella Victorelli and Joao Passos Chapter 8: Modelling cellular ageing: mathematical and computational approaches. by: Tarynn M. Witten Section III AGEING, CANCER and senescenceChapter 9: Cell cycle checkpoints and senescence. by: Renu Wadhwa, Zeenia Kaul and Sunil C. Kaul Chapter 10: Mitochondrial reactive oxygen species in cellular senescence. by: Timothy Nacarelli, Claudio Torres and Christian Sell Chapter 11: Cellular aging and tumour regulation. by: Andreas Simm, Barbara Seliger and Lars-Oliver Klotz Chapter 12: Biomarkers of replicative senescence revisited. by: Jan Nehlin Section IV AGEING ModulatORSChapter 13: Stress-induced (premature) senescence. by: Florence Debacq-Chainiaux, Randa Ben Ameur, Emilie Bauwens, Elise Dumortier, Marie Toutfaire and Olivier Toussaint Chapter 14: Implications of cellular senescence on aging and disease in the brain. by: Elizabeth P. Crowe, S. Ferit Tuzer, Justin Cohen, Emre C. Yetkin, Luca D’Agostino, Christian Sell and Claudio Torres Chapter 15: Small non coding RNAs in senescence and aging. by: Joseph Dhahbi Chapter 16: Targeting senescent cells to improve huan health by: Tobias Wijshake and Jan M. A. van Deursen Section V RECAPITULATION AND FUTURE EXPECTATIONSChapter 17: Unlike the stochastic events that determine ageing, sex determines longevity. by: Leonard Hayflick Index

Erscheint lt. Verlag	9.5.2016
Reihe/Serie	Healthy Ageing and Longevity
Zusatzinfo	VIII, 364 p. 27 illus., 18 illus. in color.
Verlagsort	Cham
Sprache	englisch
Themenwelt	Medizin / Pharmazie ► Medizinische Fachgebiete
	Naturwissenschaften ► Biologie
	Technik
Schlagworte	Ageing • Cancer • Cell Cycle Regulation • cytogenetics • Longevity • Stress
ISBN-10	3-319-26239-4 / 3319262394
ISBN-13	978-3-319-26239-0 / 9783319262390

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