Peptides: Chemistry and Biology (eBook)

Norbert Sewald studied Chemistry at the Technical University of Munich, Germany, where he also obtained his PhD degree. After postdoctoral work with J. E. Baldwin in Oxford, UK, he became an Assitant Professor at Leipzig University. Since 1999 he is full Professor at the University of Bielefeld where he holds the chair in Organic and Bioorganic Chemistry. His main scientific interest is in peptide chemistry, bioactive peptides., and their application in biochemistry and medical sciences. He has authored more than 120 publications and together with Hans-Dieter Jakubke, has written the book Peptides from A - Z, also published by Wiley-VCH. Hans-Dieter Jakubke studied Chemistry at the Martin-Luther-University Halle-Wittenberg, Germany. After finishing his PhD and postdoctoral work with Josef Rudinger in Prague (Czeck Republic), he was appointed Assistant Professor at the Department of Biochemistry in Halle, and Full Professor of Biochemistry at the University of Leipzig in 1977. He was director of the Department of Biochemistry from 1993-1997 and member of the Council of the European Peptide Society from 1990-1994. He authored several textbooks and encyclopedias on various aspects of chemistry and biochemistry including peptide research.

INTRODUCTION AND BACKGROUND
FUNDAMENTAL CHEMICAL AND STRUCTURAL PRINCIPLES
Definitions and Main Conformational Features of the Peptide Bond
Building Blocks, Classification, and Nomenclature
Analysis of the Covalent Structure of Peptides and Proteins
Three-Dimensional Structure
Methods of Structural Analysis
BIOLOGY OF PEPTIDES
Historical Aspects and Biological Functions
Biosynthesis
Selected Biologically Active Peptides
PEPTIDE SYNTHESIS
Principles and Objectives
Protection of Functional Groups
Peptide Bond Formation
Racemization During Synthesis
Solid-Phase Peptide Synthesis (SPPS)
Biochemical Synthesis
SYNTHESIS CONCEPTS FOR PEPTIDES AND PROTEINS
Strategy and Tactics
Solution Phase Synthesis (SPS)
NEW: Solution Phase/Solid Phase-Hybrid Approaches
Optimized Strategies on Polymeric Support
Chemical Ligation Strategies
SYNTHESIS OF SPECIAL PEPTIDES AND PEPTIDE CONJUGATES
Cyclopeptides
Cystine Peptides
Glycopeptides
Phosphopeptides
Lipopeptides
Sulfated Peptides
PEPTIDE AND PROTEIN DESIGN, PSEUDOPEPTIDES, AND PEPTIDOMIMETICS
Peptide Design
Modified Peptides
Peptidomimetics
Pseudobiopolymers
Macropeptides and De-Novo Design of Peptides and Proteins
COMBINATORIAL PEPTIDE SYNTHESIS
Parallel Synthesis
Synthesis of Mixtures
APPLICATION OF PEPTIDES AND PROTEINS
NEW: General Production Strategies
NEW: Improvement of the Therapeutic Potential
Protein Pharmaceuticals
Peptide Pharmaceuticals
PEPTIDES IN PROTEOMICS
NEW: Genome and Proteome
NEW: Separation Methods
NEW: Peptide and Protein Analysis in Proteomics
NEW: Activity-Based Proteomics