Bioinspired and Biomimetic Systems for Drug and Gene Delivery (eBook)

Professor Zhongwei Gu received his B. Sci. and M. Sci in Polymer Science from Peking University, prior to serving as a senior visiting scholar in the Research Triangle Institute, RTP and the University of Utah, respectively from 1984 to 1986 and 1991 to 1993. He was appointed as a professor in 1994, and presently serves as the chief scientist of the National Basic Research Program of China (the 973 program), director of the National Engineering Research Center for Biomaterials at Sichuan University, vice-chairman of the Chinese Society for Biomaterials (CSBM), executive member of the council of the Chinese Materials Research Society (C-MRS) and Chinese Society for Biomedical Engineering (CSBME) and is a Fellow of international Biomaterials Science and Engineering (FBSE). His current research activities focus on the molecular design and controlled preparation of novel biomedical polymers, self-assembled biomaterials and nano-biomaterials, vectors for gene therapy, polymeric carriers and controlled drug delivery systems, biomaterials for molecular diagnosis, and biodegradable scaffolds for tissue engineering. Professor Zhongwei Gu has thrice being Chief Scientist of National Basic Research Program of China (National 973 Program) (1999-2004, 2005-2010, 2010-2015) and has being the PI of about 30 funding and research projects. Until now he has published more than 270 papers in Adv. Mater., Angew. Chem. Int. Ed., ACS Nano, Adv. Funct. Mater., Biomaterials, J. Control. Rel. and so on. He also has ~25 patents, composes/translates ~12 books and chapters, and is the invited speaker in many international and domestic conferences.

Preface

BACKBONE DEGRADABLE AND COILED-COIL BASED MACROMOLECULAR THERAPEUTICS
Introduction
Water-Soluble Polymers as Carriers of Anticancer Drugs
Drug-Free Macromolecular Therapeutics - A New Paradigm in Drug Delivery
General Summary and Outlook

DENDRITIC POLYMERS AS TARGETING NANOSCALE DRUG DELIVERY SYSTEMS FOR CANCER THERAPY
Introduction
Functional Dendritic Polymers Based Drug Delivery Vehicles for Targeting Tumor Therapy via EPR Effect
Tumor Targeting Moieties Functionalized Dendritic Drug Delivery Vehicles for Cancer Therapy
Conclusion

COMPOSITE COLLOIDAL NANOSYSTEMS FOR TARGETED DELIVERY AND SENSING
Introduction
Objective
Cellular Behavior of the Carrier
Applications
Conclusions

POLYMERIC MICELLES FOR CANCER-TARGETED DRUG DELIVERY
Introduction
Micelle Formulations in Clinical Development
Particle Size of Micelles
Morphology of Micelles
Targeting Designs of Micelles for Enhanced Accumulation and Cell Internalization
Functional Designs of Micelles
Design of Micelles for Gene Delivery
Challenge and Future Perspective

BIOMIMETIC POLYMERS FOR IN VIVO DRUG DELIVERY
Introduction
Commonly Used Biomimetic Polymers and Their Applications in DDS
Challenges and Perspectives

DRUG DELIVERY FROM PROTEIN-BASED NANOPARTICLES
Introduction
Preparation and Protein-Based Nanoparticles
Drug Delivery from Albumin-Based Nanoparticles
Drug Delivery from Gelatine-Based Nanoparticles
Drug Delivery from Other Protein-Based Nanoparticles

POLYMERIC GENE CARRIERS
Gene Therapy and Gene Carriers
Polymeric Gene Carriers
PEI Grafting Modification Polmeric Gene Carrriers
Low Molecular Weight (LWM) PEI Base Polymeric Gene Carriers
Targeted Shielding System for Polymeric Gene Carriers
Conclusion

pH-SENSITIVE POLYMERIC NANOPARTICLES AS CARRIERS FOR CANCER THERAPY AND IMAGING
Introduction
pH-Sensitive Polymers
pH-Sensitive Polymers as Drug Carriers
pH-Sensitive Polymers for Bioimaging
Conclusions

CHARGE-REVERSAL POLYMERS FOR BIODELIVERY
Applications of Cationic Polymers in Biodelivery
Barriers for Cationic Polymers in In Vitro and In Vivo Applications
Characteristic pH Gradients in Tumor Interstitium and Endo/Lysosomes
Chemistry of Charge-Reversal Polymers Based on Acid-Labile Amides
Applications of Charge-Reversal Polymers in Biodelivery Systems
Perspectives

PHENYLBORONIC ACID-CONTAINING GLUCOSE-RESPONSIVE POLYMER MATERIALS: SYNTHESIS AND APPLICATIONS IN DRUG DELIVERY
Introduction
PBA-Containing Polymers Operating Under Physiological Conditions
Chemically Crosslinked PBA-Based Gels
Self-Assembled PBA-Based Polymer Micelles
Self-Assembled PBA-Based Polymersomes
Perspectives

EXTRACELLULAR pH-ACTIVATED NANOCARRIERS FOR ENHANCED DRUG DELIVERY TO TUMORS
Introduction
Passive and Active Tumor Targeting
Targeting the Extracellular pH (pHe) in Tumors
Extracellular pH-Induced Drug Delivery to Tumors
Ligand Exposure by a Shielding/Deshielding Method
Surface Charge Reversing Nanoparticles
Conclusion

STIMULATION-SENSITIVE DRUG DELIVERY SYSTEMS
Introduction
pH-Sensitive Delivery Systems
Thermo-Sensitive Delivery Systems
Biomolecule-Sensitive Delivery Systems
Other Environmentally Sensitive Nanocarriers
Outlook

Index