This series continually publishes cutting-edge reviews in the rapidly evolving field of genetics.
The field of genetics is rapidly evolving, and new medical breakthroughs are occurring as a result of advances in our knowledge of genetics. Advances in Genetics continually publishes important reviews of the broadest interest to geneticists and their colleagues in affiliated disciplines. Volume 87 presents an eclectic mix of articles of use to all human and molecular geneticists on topics including: gene transfer, fruiting body development and the genetics of Alzheimer's disease; and more. Includes methods for testing with ethical, legal, and social implications Critically analyzes future directions Written and edited by recognized leaders in the field
Front Cover 1
Advances in Genetics 4
Copyright 5
CONTENTS 6
CONTRIBUTORS 8
1 - Opportunity for Selection in Human Health 10
1. INTRODUCTION 11
2. GENETIC VARIATION AND DEMOGRAPHIC SELECTION 17
3. EPISODES OF SELECTION 24
4. SELECTION SPECTRA 38
5. PLACE OF MULTILEVEL SELECTION IN MEDICAL PRACTICE AND PUBLIC HEALTH 52
6. DISCUSSION 60
ACKNOWLEDGMENTS 64
REFERENCES 64
2 - Clinical Applications Involving CNS Gene Transfer 80
1. INTRODUCTION 81
2. CNS CLINICAL TRIALS UTILIZING RETROVIRAL VECTORS 84
3. CNS CLINICAL TRIALS UTILIZING AAV VECTORS 101
4. LESSONS LEARNED FROM RELATED STUDIES 117
5. CONCLUSION 119
REFERENCES 120
3 - Methods for Gene Transfer to the Central Nervous System 134
1. INTRODUCTION 135
2. VECTORS FOR CNS GENE TRANSFER 136
3. GENOME DESIGNS FOR OPTIMAL EXPRESSIONS 177
4. CONCLUSIONS 186
REFERENCES 187
4 - The Filamentous Fungus Sordaria macrospora as a Genetic Model to Study Fruiting Body Development 208
1. INTRODUCTION 209
2. GENETIC AND GENOMIC TOOLS 211
3. THE STRIATIN-INTERACTING PHOSPHATASE AND KINASE COMPLEX, A MULTISUBUNIT PROTEIN COMPLEX GOVERNING FRUITING BODY DEVELOPMENT 219
4. CHROMATIN-RELATED PROCESSES 223
5. METABOLISM-RELATED DEVELOPMENTAL PROCESSES 227
6. AUTOPHAGY 236
7. CONCLUDING REMARKS AND OUTLOOK 242
ACKNOWLEDGMENTS 243
REFERENCES 243
5 - Genetics of Alzheimer’s Disease 254
1. INTRODUCTION 255
2. HERITABILITY OF ALZHEIMER’S DISEASE 257
3. GENETIC CAUSES OF EARLY-ONSET ALZHEIMER’S DISEASE 258
4. GENETIC RISK FACTORS FOR LATE-ONSET ALZHEIMER’S DISEASE 260
5. DISCUSSION 284
REFERENCES 287
INDEX 304
Opportunity for Selection in Human Health
Abstract
Natural selection defined by differential survival and reproduction of individuals in populations is influenced by genetic, developmental, and environmental factors operating at every age and stage in human life history: generation of gametes, conception, birth, maturation, reproduction, senescence, and death. Biological systems are built upon a hierarchical organization nesting subcellular organelles, cells, tissues, and organs within individuals, individuals within families, and families within populations, and the latter among other populations. Natural selection often acts simultaneously at more than one level of biological organization and on specific traits, which we define as multilevel selection. Under this model, the individual is a fundamental unit of biological organization and also of selection, imbedded in a larger evolutionary context, just as it is a unit of medical intervention imbedded in larger biological, cultural, and environmental contexts. Here, we view human health and life span as necessary consequences of natural selection, operating at all levels and phases of biological hierarchy in human life history as well as in sociological and environmental milieu. An understanding of the spectrum of opportunities for natural selection will help us develop novel approaches to improving healthy life span through specific and global interventions that simultaneously focus on multiple levels of biological organization. Indeed, many opportunities exist to apply multilevel selection models employed in evolutionary biology and biodemography to improving human health at all hierarchical levels. Multilevel selection perspective provides a rational theoretical foundation for a synthesis of medicine and evolution that could lead to discovering effective predictive, preventive, palliative, potentially curative, and individualized approaches in medicine and in global health programs.
Keywords
Developmental demography; Evolution and medicine; Fitness; Genetic disease burden; Identity-by-context; Individualized medicine; Lansing range; Multilevel selection; Population structure; Units and targets of selection
Natural selection acts only tentatively.
…loss of fitness is the price paid by a species for its capacity for further evolution.
Natural selection is multilevel: A phenotypic target can exist at any level of biological organization, from macromolecular to chromosomes to eukaryotic cells to multicellular organisms, and onto organized social groups, populations of organisms and groups, and finally, arguably, entire ecosystems.
1. Introduction
Erscheint lt. Verlag | 9.10.2014 |
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Sprache | englisch |
Themenwelt | Naturwissenschaften ► Biologie ► Genetik / Molekularbiologie |
Naturwissenschaften ► Biologie ► Zellbiologie | |
Technik | |
ISBN-10 | 0-12-800369-3 / 0128003693 |
ISBN-13 | 978-0-12-800369-5 / 9780128003695 |
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