Synaptic Stress and Pathogenesis of Neuropsychiatric Disorders (eBook)

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2014 | 2014
XIV, 355 Seiten
Springer New York (Verlag)
978-1-4939-1056-4 (ISBN)

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Recent studies show that changes in Glutamate/GABA synapses and related pathways may determine whether the synaptic plasticity that occurs as a response to stress is adaptive or maladaptive. Findings have shed new light on the mechanisms that determine the effects of stress on cognitive and affective function. Researchers have brought a wide range of techniques to bear on the study of this problem, including cutting-edge live imaging techniques, electrophysiology, glutamate release from isolated live synaptic terminals, development of transgenic and animal models and new behavioral methods. This book provides an overview of these recent findings and of the techniques used as well as a discussion of how the molecular, cellular, and functional effects of stress may trigger or precipitate neuropsychiatric disorders such as depression, schizophrenia, anxiety and PTSD.
Recent studies show that changes in Glutamate/GABA synapses and related pathways may determine whether the synaptic plasticity that occurs as a response to stress is adaptive or maladaptive. Findings have shed new light on the mechanisms that determine the effects of stress on cognitive and affective function. Researchers have brought a wide range of techniques to bear on the study of this problem, including cutting-edge live imaging techniques, electrophysiology, glutamate release from isolated live synaptic terminals, development of transgenic and animal models and new behavioral methods. This book provides an overview of these recent findings and of the techniques used as well as a discussion of how the molecular, cellular, and functional effects of stress may trigger or precipitate neuropsychiatric disorders such as depression, schizophrenia, anxiety and PTSD.

1. The Brain on Stress: The Good and the BadBruce S. McEwen2. Regulation of Excitatory Synapses by Stress HormonesMarian Joëls, Harm Krugers, Henk Karst3. Synaptic Stress, Changes in Glutamate Transmission and Circuitry, and PsychopatologyLaura Musazzi, Giulia Treccani, Carla Perego, Nicoletta Nava, Jens R Nyengaard, Maurizio Popoli4. Dual Regulation of Glutamatergic Transmission and Cognition by Stress in Prefrontal Cortex Zhen Yan5. Role of Endocannabinoids in Regulating Glucocorticoid Effects on Memory for Emotionally Arousing ExperiencesPiray Atsak, Benno Roozendaal, Patrizia Campolongo6. Endocannabinoid Signaling & Synaptic Plasticity During StressJ. Megan Gray, Haley A. Vecchiarelli, Matthew N. Hill7. Stress Induced Metaplasticity at GABA SynapsesJaideep S. Bains8. Stress Modulation of Synaptic Plasticity in the HippocampusMenahem Segal, Nicola Maggio9. Neural-Cognitive Effects of Stress in the HippocampusJeansok J. Kim, Blake A. Pellman, Eun Joo Kim10. Evolutionary, Historical and Mechanistic Perspectives on How Stress Affects Memory and Hippocampal Synaptic PlasticityGeorge E. Farmer, Collin R. Park, Laura A. Bullard, David M. Diamond11. Acute Stress Disrupts Short- and Long-term Patterns of Synaptic Plasticity in Dorsal Hippocampus and Subiculum: Implications for Hippocampal Output and BehaviourJohn G. Howland, Don A. Davies12. Synaptic Mechanisms and Cognitive Computations Underlying Stress Effects on Cognitive FunctionGediminas Luksys, Carmen Sandi13. Altered GABA Function in Major DepressionBeverly French, Marianne L. Seney, Etienne Sibille14. Pathology in Astroglia, Glutamate and GABA in Major Depressive Disorder: Evidence from Studies of Human Postmortem TissueGrazyna Rajkowska15. Evidence of Glutamatergic Dysfunction in the Pathophysiology of SchizophreniaJ.C. Hammond, D. Shan, J.H. Meador-Woodruff, R.E. McCullumsmith16. Metabolic Stress and Neuropsychiatric DisordersClaudia A. Grillo, Lawrence P. Reagan17. Using our Understanding of Stress Related Effects on Glutamate Neurotransmission to Guide the Development of Novel Treatment StrategiesCarly Kiselycznyk, Gerard Sanacora

Erscheint lt. Verlag 28.7.2014
Zusatzinfo XIV, 355 p. 49 illus., 48 illus. in color.
Verlagsort New York
Sprache englisch
Themenwelt Medizin / Pharmazie Medizinische Fachgebiete Neurologie
Medizin / Pharmazie Medizinische Fachgebiete Psychiatrie / Psychotherapie
Medizin / Pharmazie Studium
Naturwissenschaften Biologie Humanbiologie
Naturwissenschaften Biologie Zoologie
Technik
Schlagworte Glutamate • mood/anxiety disorders • Stress • synaptic plasticity • synaptic transmission
ISBN-10 1-4939-1056-6 / 1493910566
ISBN-13 978-1-4939-1056-4 / 9781493910564
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