Synaptic Stress and Pathogenesis of Neuropsychiatric Disorders

Maurizio Popoli, David Diamond, Gerard Sanacora (Herausgeber)

Buch | Hardcover

355 Seiten

2014 | 2014 ed.
Springer-Verlag New York Inc.
978-1-4939-1055-7 (ISBN)

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Recent studies show that changes in Glutamate/GABA synapses and related pathways may determine whether the synaptic plasticity that occurs as a response to stress is adaptive or maladaptive. Findings have shed new light on the mechanisms that determine the effects of stress on cognitive and affective function. Researchers have brought a wide range of techniques to bear on the study of this problem, including cutting-edge live imaging techniques, electrophysiology, glutamate release from isolated live synaptic terminals, development of transgenic and animal models and new behavioral methods. This book provides an overview of these recent findings and of the techniques used as well as a discussion of how the molecular, cellular, and functional effects of stress may trigger or precipitate neuropsychiatric disorders such as depression, schizophrenia, anxiety and PTSD.

1. The Brain on Stress: The Good and the Bad
Bruce S. McEwen

2. Regulation of Excitatory Synapses by Stress Hormones
Marian Joëls, Harm Krugers, Henk Karst

3. Synaptic Stress, Changes in Glutamate Transmission and Circuitry, and Psychopatology
Laura Musazzi, Giulia Treccani, Carla Perego, Nicoletta Nava, Jens R Nyengaard, Maurizio Popoli

4. Dual Regulation of Glutamatergic Transmission and Cognition by Stress in Prefrontal Cortex Zhen Yan

5. Role of Endocannabinoids in Regulating Glucocorticoid Effects on Memory for Emotionally Arousing Experiences
Piray Atsak, Benno Roozendaal, Patrizia Campolongo

6. Endocannabinoid Signaling & Synaptic Plasticity During Stress
J. Megan Gray, Haley A. Vecchiarelli, Matthew N. Hill

7. Stress Induced Metaplasticity at GABA Synapses
Jaideep S. Bains

8. Stress Modulation of Synaptic Plasticity in the Hippocampus
Menahem Segal, Nicola Maggio

9. Neural-Cognitive Effects of Stress in the Hippocampus
Jeansok J. Kim, Blake A. Pellman, Eun Joo Kim

10. Evolutionary, Historical and Mechanistic Perspectives on How Stress Affects Memory and Hippocampal Synaptic Plasticity
George E. Farmer, Collin R. Park, Laura A. Bullard, David M. Diamond

11. Acute Stress Disrupts Short- and Long-term Patterns of Synaptic Plasticity in Dorsal Hippocampus and Subiculum: Implications for Hippocampal Output and Behaviour
John G. Howland, Don A. Davies

12. Synaptic Mechanisms and Cognitive Computations Underlying Stress Effects on Cognitive Function
Gediminas Luksys, Carmen Sandi

13. Altered GABA Function in Major Depression
Beverly French, Marianne L. Seney, Etienne Sibille

14. Pathology in Astroglia, Glutamate and GABA in Major Depressive Disorder: Evidence from Studies of Human Postmortem Tissue
Grazyna Rajkowska

15. Evidence of Glutamatergic Dysfunction in the Pathophysiology of SchizophreniaJ.C. Hammond, D. Shan, J.H. Meador-Woodruff, R.E. McCullumsmith

16. Metabolic Stress and Neuropsychiatric Disorders
Claudia A. Grillo, Lawrence P. Reagan

17. Using our Understanding of Stress Related Effects on Glutamate Neurotransmission to Guide the Development of Novel Treatment Strategies
Carly Kiselycznyk, Gerard Sanacora

Zusatzinfo	13 Tables, black and white; 48 Illustrations, color; 1 Illustrations, black and white; XIV, 355 p. 49 illus., 48 illus. in color.
Verlagsort	New York
Sprache	englisch
Maße	155 x 235 mm
Gewicht	6801 g
Themenwelt	Medizin / Pharmazie ► Medizinische Fachgebiete ► Neurologie
	Medizin / Pharmazie ► Medizinische Fachgebiete ► Psychiatrie / Psychotherapie
	Medizin / Pharmazie ► Studium
	Naturwissenschaften ► Biologie ► Humanbiologie
	Naturwissenschaften ► Biologie ► Zoologie
Schlagworte	Glutamate • mood/anxiety disorders • Stress • synaptic plasticity • synaptic transmission
ISBN-10	1-4939-1055-8 / 1493910558
ISBN-13	978-1-4939-1055-7 / 9781493910557
Zustand	Neuware