Bioactive Natural Products Detection, Isolation, and Structural Determination

Colegate; Steven M. Geelong, Australia,Molyneux; Russell J. ,

Introduction and Overview (S.M. Colegate and R.J. Molyneux). Detection and Isolation of Bioactive Natural Products (E. Ghisalberti). Water Soluble Alkaloids: Cryptic Bioactive Natural Products (R.J. Molyneux). Nuclear Magnetic Resonance Spectroscopy: Strategies for Structural Determination (L.T. Byrne). Mass Spectrometry (S.J. Bloor and L.J. Porter). Determination of Three-Dimensional Structure and Configuration of Bioactive Natural Compounds by X-Ray Crystallography (R.Y. Wong and W. Gaffield). Determination of the Absolute Configuration of Bioactive Natural Compounds Utilizing Exciton Chirality Circular Dichroism (W. Gaffield). Acquisition and Screening of Natural Products as Potential Anticancer and AIDS-Antiviral Agents (D. Lednicer and V.L. Narayanan). Potently Sweet Compounds from Plants: Techniques of Isolation and Identification (A.D. Kinghorn and J. Kim). Separation, Structure Elucidation, and Bioassay of Cytotoxic Natural Products (G.A. Cordell, A.D. Kinghorn, and J.M. Pezzuto). Cytoinhibitory Compounds from Higher Plants (A. Marston, L.A. Decosterd, and K. Hostettmann). Insect Behavior Modifiers (S. Takahashi). Assessment of Anti-Inflammatory Activity of Natural Products (K.D. Croft). Immunomodulatory Compounds (R.P. Labadie). Biologically Active Terpenoids and Aromatic Compounds from Liverworts and the Inedible Mushroom Cryptoporus volvatus (Y. Asakawa). General Strategy for the Structure Determination of Saponins: Molluskicidal Saponins from Allium vineale (S. Chen and J.K. Snyder). Antiviral Agents from Higher Plants and an Example of Structure-Activity Relationship of 3-Methoxyflavones (D. Vanden Berghe, A. Haemers, and A. Vlietinck). Toxicity Testing Using the Brine Shrimp, Artemia salina (T.W. Sam). In Vitro Neurotoxicity Bioassay: Neurotoxicity of Sesquiterpene Lactones (R.J. Riopelle and K.L. Stevens). Ultrasound Imaging: A Bioassay Technique to Monitor Fetotoxicity of Natural Toxicants and Teratogens (K.E. Panter). Plants Affecting Livestock: An Approach to Toxin Isolation (P.R. Dorling, S.M. Colegate, and C.R.R. Huxtable).