GTPases in Biology I

Section I: Biological Importance of GTPase-Driven Switches.- 1 GTPases Everywhere!.- 2 Proofreading in the Elongation Cycle of Protein Synthesis.- 3 A New Look at Receptor-Mediated Activation of a G-Protein.- 4 Small GTPases and Vesicle Trafficking: Sec4p and its Interaction with Up- and Downstream Elements.- 5 Cytoskeletal Assembly: The Actin and Tubulin Nucleotidases.- 6 Dynamin, A Microtubule-Activated GTPase Involved in Endocytosis.- 7 Transmembrane Protein Translocation: Signal Recognition Particle and Its Receptor in the Endoplasmic Reticulum.- 8 GTPases and Actin as Targets for Bacterial Toxins.- Section II. Structure of the GTPase Switches.- 9 Eukaryotic Translation Factors Which Bind and Hydrolyze GTP.- 10 Heterotrimeric G-Proteins: ?, ?, and ? Subunits.- 11 Molecular Diversity in Signal Transducing G-Proteins.- 12 Structural Conservation of Ras-Related Proteins and Its Functional Implications.- 13 Conformational Switch and Structural Basis for Oncogenic Mutations of Ras Proteins.- 14 Structural and Mechanistic Aspects of the GTPase Reaction of H-ras p21.- 15 Analysis of Ras Structure and Dynamics by Nuclear Magnetic Resonance.- 16 Molecular Dynamics Studies of H-ras p21-GTP.- Section III: Small Ras - Related GTPases.- A. Control of Growth and Differentiation by the Ras Family.- 17 The Discovery of Ras and Its Biological Importance.- 18 Oncogenic Activation of ras Proteins.- 19 Dominant Inhibitory Ras Mutants: Tools for Elucidating Ras function.- 20 The Involvement of Cellular ras in Proliferative Signaling.- 21 Regulation of Ras-Interacting Proteins in Saccharomyces cerevisiae.- 22 Lipid Modifications of Proteins in the Ras Superfamily.- 23 GTPase Activating Proteins.- 24 Guanine Nucleotide Dissociation Stimulators.- 25 The Biology of Rap.- B. VesicleTransfer/Vesicle Fusion.- 26 GTPases and Interacting Elements in Vesicle Budding and Targeting in Yeast.- 27 Ypt Proteins in Yeast and Their Role in Intracellular Transport.- 28 Compartmentalization of rab Proteins in Mammalian Cells.- 29 GTPases in Transport Between Late Endosomes and the Trans Golgi Network.- 30 Endocytic Function in Cell-Free System.- 31 Synaptic Vesicle Membrane Traffic and the Cycle of Rab3.- 32 Regulated Exocytosis and Interorganelle Vesicular Traffic: A Comparative Analysis.- 33 Regulated and Constitutive Secretion Studied In Vitro: Control by GTPases at Multiple Levels.- 34 The Biology of ADP-Ribosylation Factors.- 35 Molecular Characterization of ADP-Ribosylation Factors.- C. rho and rho-Like Proteins.- 36 rho and rho-Related Proteins.- 37 The Mammalian Homolog of the Yeast Cell-Division-Cycle Protein, CDC42: Evidence for the Involvement of a Rho-Subtype GTPase in Cell Growth Regulation.- D. Regulation of and by Small GTPases.- 38 Role of Rap1B and Its Phosphorylation in Cellular Function: A Working Model.- 39 GDP/GTP Exchange Proteins for Small GTP-Binding Proteins.- 40 GTP-Mediated Communication Between Intracellular Calcium Pools.- 41 Coupling of ras to the T Cell Antigen Receptor.- 42 GTPases as Regulators of Regulated Secretion.- 43 ADP-Ribosylation of Small GTPases by Clostridium botulinum Exoenzyme C3 and Pseudomonas aeruginosa Exoenzyme S.