GTPhases in Biology

A two-volume survey of the major classes of GTPases, which examines the role of GTPases in ensuring accuracy during protein translation, the timeric G-protein cycle, the molecular function of ARF in vesicle coating, cytoskeletal polymerization and vesicle transfer, among other topics.

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Recent advances in molecular biology have shown GTPases and phosphoproteins to be the paramount molecular switches utilized intracellularly in biological systems. The origins of the GTPase switch appear to be almost as ancient as life itself, and through evolution nature has adapted this switch to a variety of purposes. In this two-volume work, a broad survey of the major classes of GTPases is presented. The role of GTPases in ensuring accuracy during protein translation, the trimeric G-protein cycle, the molecular function of ARF in vesicle coating, the emerging role of the dynamin family in vesicle transfer, GTPases which activate GTPases during nascent protein translocation, and the many roles of ras-related proteins in growth, cytoskeletal polymerization and vesicle transfer, are all described in 80 chapters by leading authorities in their fields. Both detailed knowledge of specific systems or proteins and general principles of structure and function are offered. Much of this information has never been published before.