Standard Operating Procedures Analytical Chemistry and Metabolism

Standard Operating Procedures.- General procedures.- SOP/TSB/001 Chemical test sample reception.- SOP/TSB/002 Test substance formulation — general procedures.- SOP/TSB/004 Test substance handling and safety procedures.- SOP/TSB/005 Handling and safety procedures for operations involving hazardous materials or potentially hazardous materials.- SOP/TSB/020 The use of radioactive substances at IRI — a summary of operating procedures.- SOP/TSB/021 Swab monitoring procedure for radiochemical contamination.- SOP/TSB/042 General instructions for the preparation of treated diets for use in toxicity studies.- SOP/TSB/044 Formulated test substance sampling procedures.- Analytical chemistry.- SOP/ACH/001 Data collation and record keeping in analytical chemistry.- SOP/ACH/003 Procedure for the receipt and storage of test substances and analytical standards.- SOP/ACH/004 Procedure for the receipt and storage of biological samples prior to analysis.- SOP/ACH/005 Approval of final analytical methods in analytical chemistry.- SOP/ACH/007 Archiving procedures in analytical chemistry.- SOP/ACH/008 Tube labelling and data recording during pharmacokinetic studies in animals.- SOP/ACH/009 Oral administration of test substances to human volunteers.- SOP/REC/030 Studies involving human volunteers.- SOP/ACH/101 Use and maintenance of fixed volume pipettes.- SOP/ACH/102 Use and maintenance of “class A” pipettes and standard flasks.- SOP/ACH/103 The preparation of reference standards for the generation of standard curves during analysis of plasma and urine samples.- SOP/ACH/104 Processing of analytical data derived from liquid or gas chromatograms or from selected ion-monitoring computer output.- SOP/ACH/106 Preparation of reference standards and quality control samples during analysisof dietary formulations.- SOP/ACH/201 Instructions for using the Perkin Elmer F17 gas chromatograph.- SOP/ACH/204 Operation of HPLC systems in analytical chemistry.- SOP/ACH/205 Operation of the Finnigan 4000 GC-MS system.- SOP/ACH/207 Instructions for use and calibration of the Sartorius 2404 balance for critical weighings in analytical chemistry.- Metabolism.- SOP/MET/100 General record keeping and archiving procedures (amendment for metabolic studies).- SOP/MET/101 Quality control procedures.- SOP/MET/150 Procedure for the receipt, storage and distribution of non-radioactively labelled drugs and reference standard compounds.- SOP/MET/200 Authenticity, radiochemical purity and specific activity of supplied radiochemicals prior to administration to animals and/or man.- SOP/MET/201 The preparation and determination of a radiochemical dose.- SOP/MET/205 The receipt, randomisation and numbering of animals.- SOP/MET/210 The oral and parenteral administration of radiolabeled test substances to rats.- SOP/MET/213 The oral and parenteral administration of radiolabeled test substances to dogs.- SOP/MET/214 The oral and parenteral administration of radiolabeled test substances to non-human primates.- SOP/MET/220 Procedure for the withdrawal of blood samples from rats to which radiolabeled test substance has been administered.- SOP/MET/223 Procedure for the withdrawal of blood samples from dogs to which radiolabeled test substance has been administered.- SOP/MET/224 Procedure for the withdrawal of blood samples from non-human primates to which radiolabeled test substance has been administered.- SOP/MET/230 Collection of excreta from rats to which radiolabeled test substance has been administered.- SOP/MET/233 Collection of excreta from dogs to which radiolabeled test substancehas been administered.- SOP/MET/234 Collection of excreta from non-human primates to which test substance has been administered.- SOP/MET/240 Sample collection at autopsy following administration of radiolabeled test substance.- SOP/MET/250 Procedure for the identification, receipt, storage and disposal of biological samples.- SOP/MET/255 Use of balances.- SOP/MET/260 Preparation of biological samples for analysis of radioactivity.- SOP/MET/300 Operation of the Packard 306 sample oxidiser.- SOP/MET/310 Routine use of the Philips PW 4510/01 automatic liquid scintillation analyser.- SOP/MET/320 Processing of data from the scintillation counter with particular reference to acceptance and rejection criteria.- SOP/MET/330 The topical administration of test substances to rats.- SOP/MET/340 Whole body autoradiography.- SOP/MET/350 The use of thin-layer chromatography.- SOP/MET/360 The use of HPLC systems in the operational area of metabolic studies.