Mitochondrial DNA Mutations in Aging, Disease and Cancer

Buch | Softcover

XX, 412 Seiten

2013 | 1. Softcover reprint of the original 1st ed. 1998
Springer Berlin (Verlag)
978-3-662-12511-3 (ISBN)

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Many human genetic diseases associated with blood, brain, colon, ear, eye, heart, kidney, liver, muscle, and pancreas are caused by mutations in mitochondrial DNA. Mutations in DNA can result in defects of the electron transport complexes, intermediates of the tricarboxylic acid cycle and substrate transport. The clinical manifestation of these diseases often involves muscle and the nervous system. Mitochondrial DNA mutations have now been associated with aging as well as age-related degenerative diseases such as Parkinson's, Alzheimer's, and Huntington's diseases. Changes in structure, function, and a number of mitochondria play an important role in carcinogenesis. Furthermore, the role of mitochondria in the execution of programmed cell death or apoptosis has been recognized recently.

1. Introduction.- 2. Mitochondrial Structure, Function and Biogenesis.- 3. The Mitochondrial Genetic System.- 4. Inheritance of Mitochondrial Mutations.- 5. Mitochondrial DNA Replication.- 6. Genetic Integrity of the Mitochondrial Genome.- 7. Modeling Mitochondrial DNA Mutations.- 8. Mitochondrial Regulation of Apoptosis.- 9. Characteristics of Mitochondrial DNA Diseases.- 10. Nuclear Defects Affecting Mitochondrial Function.- 11. Mitochondrial DNA Mutations in Aging.- 12. Mitochondrial DNA Mutations and Heart Disease.- 13. Mitochondrial Dysfunction and Neurodegenerative Diseases.- 14. Toxin Induced Mitochondrial Dysfunction and Neurodegeneration.- 15. Perspectives on Mitochondria in Carcinogenesis.- 16. The Mitochondrion as a Target for Cancer Chemotherapy.- 17. Prohibitin: Mitochondrial Tumor Suppressor Protein.- 18. Abnormal Growth and Male Sterility Associated with Mitochondrial DNA Rearrangements in Plants.- 19. Mitochondrial Disorder and Migraine.- 20. Gene Therapy of Mitochondrial DNA Diseases.- Color Figures.

Erscheint lt. Verlag	11.1.2013
Zusatzinfo	XX, 412 p. 48 illus., 6 illus. in color.
Verlagsort	Berlin
Sprache	englisch
Gewicht	747 g
Themenwelt	Medizin / Pharmazie ► Medizinische Fachgebiete ► Onkologie
	Studium ► 2. Studienabschnitt (Klinik) ► Humangenetik
	Naturwissenschaften ► Biologie ► Biochemie
	Naturwissenschaften ► Biologie ► Mikrobiologie / Immunologie
	Naturwissenschaften ► Biologie ► Zellbiologie
Schlagworte	aging • Altern • Altern / Älterwerden / Altwerden • Alzheimer Krankheit • Alzheimer's disease • Apoptosis • Cancer • cell death • DNA • Huntington-Krankheit • Huntington's diesease • Krebs • mitochondria • Mitochondrien • Oncology • Onkology • Parkinsonsche Krankheit • Parkinson's Disease • Zelltod
ISBN-10	3-662-12511-0 / 3662125110
ISBN-13	978-3-662-12511-3 / 9783662125113
Zustand	Neuware