Mitochondrial DNA Mutations in Aging, Disease and Cancer

A comprehensive and current analysis of the role of mitochondrial DNA mutations in many human genetic diseases, in ageing and age-related degenerative disorders, in carcinogenesis and in the execution of programmed cell death or apoptosis.

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This volume presents a comprehensive and current analysis of the role of mitrochondria in aging and diseases. Many human genetic diseases associated with blood, brain, colon, ear, eye, heart, kidney, liver, muscle and pancreas in humans are caused by mutations in mitochondrial DNA. Mitochondrial DNA mutations have now been associated with aging and age-related degenerative diseases such as Parkinson's, Huntigton's and Alzheimer's diseases. Changes in structure, function and a number of mitochondria play an important role in carcinogenesis, and the role of mitochondria in the execution of programmed cell death or apoptosis has been recognized.