Movement Disorders

Mark S. LeDoux, MD, PhD is a physician-scientist at the University of Tennessee Health Science Center. At present he holds a joint appointment as Professor in the Departments of Neurology, and Anatomy and Neurobiology. He specializes in the neurological subspecialty of movement disorders and treats patients at the University of Tennessee Medical Group and Memphis VA hospital. As an active clinical researcher, Dr. LeDoux’s work has focused on the genetics and treatment of dystonia, Parkinson disease and Huntington disease. He has described Huntington disease in a nonagenarian and reported one of the world’s largest pedigrees with HDL2. In the laboratory, Dr. LeDoux has published extensively on the genetics and molecular biology of dystonia, mechanisms of cell death in Parkinson’s disease, animal models of dystonia and autism, and the neuroanatomy of motor systems. His work with the dt rat engendered paradigm shifts in dystonia and motor systems research. Dr. LeDoux’s lab showed that familial and sporadic adult-onset primary dystonia may be associated with rare sequence variants in THAP1 and CIZ1.

Section I. Scientific Foundations

Section II. Parkinson Disease

Section III. Dystonia; Dystonia: Phenotypes and Genetics

Section IV. Huntington Disease

Section V. Tremor

Section VI. Myoclonus

Section VII. Tics

Section VIII. Paroxysmal Movement Disorders

Section IX. Tauopathies

Section X. Other Parkinsonian Syndromes: NBIA, MSA, PD+spasticity, PD+dystonia

Section XI. Ataxias

Section XII. Hereditary Spastic Paraplegia

Section XIII. Restless Legs Syndrome