Bioinorganic Chemistry

Dieter Rehder is a Professor in the Institute of Inorganic and Applied Chemistry, University of Hamburg where his main fields of research include organometallic, bioinorganic and medicinal chemistry (of vanadium), oxido- and sulfidometal clusters, and metal NMR. Dieter was winner of the Vanadis Award 2006 for outstanding research in the field of vanadium chemistry.

Introduction ; 1. Bio-Elements in the Periodic Table ; 2. Pre-Life and Early Life Forms; extremophiles ; 3. The Alkaline and Alkaline Earth Metals ; 3.1 Overview ; 3.2 Ion Channels ; 3.3 Sodium and Potassium ; 3.4 Magnesium ; 3.5 Calcium ; 4. Iron: General Features of its Inorganic Chemistry and Biochemistry ; 4.1 General, and Aqueous Chemistry ; 4.2 Mobilization, Transport, Delivery, and Mineralization of Iron ; 5. Oxygen Transport and the Respiratory Chain ; 5.1 Oxygen and oxygen transport by haemoglobin and myoglobin ; 5.2 Oxygen transport by hemerythrin and haemocyanin ; 5.3 The Respiratory Chain ; 6. Oxidoreductases Based on Iron, Manganese, and Copper ; 6.1 Ribonucleotide Reductases ; 6.2 Superoxide dismutases, superoxide Reductases, and peroxidases ; 6.3 Oxygenases and oxidases ; 7. Oxo-transfer Proteins Based on Molybdenum, Tungsten, and Vanadium ; 7.1 Molybdo- and Tungsto-pyranopterins ; 7.1.1 The Xanthine Oxidase Family ; 7.1.2 The Sulfite Oxidase Family ; 7.1.3 The Dimethylsulfoxide (DMSO) Reductase Family ; 7.2 Vanadate-dependent Haloperoxidases ; 7.3 Model Chemistry ; 8. The Sulfur Cycle ; 8.1 Environmental Sulfur Cycling ; 8.2 Biogenic Metabolism of Sulfur ; 9. Nitrogenase and Nitrogen Cycle Enzymes ; 9.1 Overview and Native Nitrogenase ; 9.2 Nitrogenase Models and Model Reactions ; 9.3 Denitrification ; 9.4 Nitric Oxide ; 10. The Methane Cycle and Nickel Enzymes ; 10.1 Introduction ; 10.2 Methanogenesis ; 10.3 Biogenic Oxidation of Methane ; 10.4 Nickel Enzymes not Involved in Methane Metabolism ; 11. Photosynthesis ; 11.1 Overview ; 11.2 The Reaction Pathway ; 11.3 Modeling Photosynthesis ; 12. The Biochemistry of Zinc ; 12.1 An Overview of Zinc ; 12.2 Zinc Enzymes ; 12.2.1 Carboanhydrases ; 12.2.2 Hydrolases ; 12.2.3 Alcohol Dehydrogenase ; 12.3 The Role of Zinc in the Transcription of Genes ; 12.4 Thioneins ; 13. Metal- and Metalloid-Carbon Bonds ; 13.1 Organometallic Compounds of Transition Metals ; 13.2 Carbon Bonds to Main Group Metals and Metalloids ; 14. Inorganics in Medicine ; 14.1 Metals and Metalloids: An Introduction ; 14.2 Dysfunction of Iron and Copper Homeostasis ; 14.2.1 Iron ; 14.2.2 Copper ; 14.3 Metals and Metalloids in Therapy ; 14.3.1 Historical and General Notes ; 14.3.2 Treatment of Arthritis with Gold Compounds ; 14.3.3 Cancer Treatment ; 14.3.4 Further Metal Based Medications ; 14.3.5 Radiopharmaceuticals ; 14.4 Metals and Metalloids in Diagnostic Imaging ; 14.5 The Toxic and Therapeutic Potential of CO, NO and H2S