Cardiovascular Genetics and Genomics for the Cardiologist (eBook)

Victor J. Dzau, MD James B. Duke Professor of Medicine, Director, Mandel Center for Hypertension and Atherosclerosis Research; and Chancellor for Health Affairs, Duke University, Durham, USA Choong-Chin Liew, PhD Professor Emeritus, Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada; and (formerly) Visiting Professor of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA

Contributors.

Foreword.

Introduction.

1 The gene in the twenty-first century.

Choong-Chin Liew, Victor J. Dzau.

Part I: Cardiovascular single gene disorders.

2 Monogenic hypercholesterolemia.

Ruth McPherson.

3 Hypertrophic cardiomyopathy.

Ali J. Marian.

4 Dilated cardiomyopathy and other cardiomyopathies.

Mitra Esfandiarei, Robert Yanagawa, Bruce M. McManus.

5 The long QT syndrome.

Sabina Kupershmidt, Kamilla Kelemen, Tadashi
Nakajima.

Part II: Cardiovascular polygenic disorders.

6 Atherosclerosis.

Päivi Pajukanta, Kiat Tsong Tan, Choong-Chin
Liew.

7 Heart failure.

Markus Meyer, Peter VanBuren.

8 The implications of genes on the pathogenesis, diagnosis and
therapeutics of hypertension.

Kiat Tsong Tan, Choong-Chin Liew.

Part III: Therapies and applications.

9 Gene therapy for cardiovascular disease: inserting new genes,
regulating the expression of native genes, and correcting genetic
defects.

Ion S. Jovin, Frank J. Giordano.

10 Stem cell therapy for cardiovascular disease.

Emerson C. Perin, Guilherme V. Silva.

11 Pharmacogenetics and personalized medicine.

Julie A. Johnson, Issam Zineh.

12 The potential of blood-based gene profiling for disease
assessment.

Steve Mohr, Choong-Chin Liew.

Index.

Colour plates

"An excellent guide for developing, reviewing, or updating a keen
understanding of genetics and its future in medicine. The book
should find wide readership."

Doodys Review