Cardiovascular Genetics and Genomics for the Cardiologist (eBook)

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2008 | 1. Auflage
328 Seiten
Wiley (Verlag)
978-0-470-76594-4 (ISBN)

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Until recently, a modest knowledge of genetics was more than adequate for the daily practice of clinical cardiology, but advances in genetics and genomics are changing cardiovascular medicine in fundamental ways. The identification of the genetic basis of several forms of dyslipidemia, hypertension, diabetes, cardiomyopathies, and vascular diseases signalled the new importance of genetics in clinical medicine.

In this timely volume, Drs. Dzau and Liew - both pioneers in the area - help cardiologists understand:
• how cardiovascular genetics may remodel the way cardiovascular medicine is practiced
• what material has immediate relevance to the practicing clinician
• how to incorporate genetics and genomics in your practice to ensure up-to-date patient care

The book opens with introductory chapters, then discusses:
• cardiovascular single gene disorders
• cardiovascular polygenic disorders
• therapies and applications

Outstanding contributors write on their areas of expertise, making Cardiovascular Genetics and Genomics for the Cardiologist both authoritative and comprehensive. If you want to gain a better appreciation of how genetics and genomics are already shaping current practice and may potentially revolutionize cardiology, look no further than this dependable reference.




Victor J. Dzau, MD
James B. Duke Professor of Medicine, Director, Mandel Center for Hypertension and Atherosclerosis Research; and Chancellor for Health Affairs, Duke University, Durham, USA

Choong-Chin Liew, PhD
Professor Emeritus, Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada; and (formerly) Visiting Professor of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA


Until recently, a modest knowledge of genetics was more than adequate for the daily practice of clinical cardiology, but advances in genetics and genomics are changing cardiovascular medicine in fundamental ways. The identification of the genetic basis of several forms of dyslipidemia, hypertension, diabetes, cardiomyopathies, and vascular diseases signalled the new importance of genetics in clinical medicine. In this timely volume, Drs. Dzau and Liew both pioneers in the area help cardiologists understand: how cardiovascular genetics may remodel the way cardiovascular medicine is practiced what material has immediate relevance to the practicing clinician how to incorporate genetics and genomics in your practice to ensure up-to-date patient care The book opens with introductory chapters, then discusses: cardiovascular single gene disorders cardiovascular polygenic disorders therapies and applications Outstanding contributors write on their areas of expertise, making Cardiovascular Genetics and Genomics for the Cardiologist both authoritative and comprehensive. If you want to gain a better appreciation of how genetics and genomics are already shaping current practice and may potentially revolutionize cardiology, look no further than this dependable reference.

Victor J. Dzau, MD James B. Duke Professor of Medicine, Director, Mandel Center for Hypertension and Atherosclerosis Research; and Chancellor for Health Affairs, Duke University, Durham, USA Choong-Chin Liew, PhD Professor Emeritus, Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada; and (formerly) Visiting Professor of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA

Cardiovascular Genetics and Genomics for the Cardiologist 1
Contents 5
Contributors 7
Foreword 9
Introduction 11
1 The gene in the twenty-first century 15
PART I Cardiovascular single gene disorders 31
2 Monogenic hypercholesterolemia 33
3 Hypertrophic cardiomyopathy 44
4 Dilated cardiomyopathy and other cardiomyopathies 69
5 The long QT syndrome 97
PART II Cardiovascular polygenic disorders 125
6 Atherosclerosis 127
7 Heart failure 151
8 The implications of genes on the pathogenesis, diagnosis and therapeutics of hypertension 180
PART III Therapies and applications 207
9 Gene therapy for cardiovascular disease: inserting new genes, regulating the expression of native genes, and correcting genetic defects 209
10 Stem cell therapy for cardiovascular disease 239
11 Pharmacogenetics and personalized medicine 264
12 The potential of blood-based gene profiling for disease assessment 291
Index 315
Colour plates are found facing 323

"An excellent guide for developing, reviewing, or updating a keen
understanding of genetics and its future in medicine. The book
should find wide readership."

Doodys Review

Erscheint lt. Verlag 15.4.2008
Sprache englisch
Themenwelt Medizin / Pharmazie Allgemeines / Lexika
Medizinische Fachgebiete Innere Medizin Kardiologie / Angiologie
Studium 2. Studienabschnitt (Klinik) Humangenetik
Naturwissenschaften Biologie Genetik / Molekularbiologie
Schlagworte Cardiovascular Disease • Kardiovaskuläre Erkrankungen • Kardiovaskuläre Erkrankungen • Medical Science • Medizin
ISBN-10 0-470-76594-1 / 0470765941
ISBN-13 978-0-470-76594-4 / 9780470765944
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