Protein Aggregation and Fibrillogenesis in Cerebral and Systemic Amyloid Disease (eBook)

I. Introduction1. Introduction and Technical Survey; J. Robin Harris and Nathaniel G. Milton II. Basic Science2. Fibril Formation by Short Synthetic Peptides; Andrew Smith 3. In vitro Oligomerization and Fibrillogenesis of Amyloid-beta Peptides; Núria  Benseny-Cases, Oksana Klementieva and Josep Cladera4. Tau Fibrillogenesis; Nitin Chaudhary and Ramakrishnan Nagaraj5. Prion protein Aggregation and Fibrillogenesis In vitro; Jan Stöhr6. α-Synuclein Aggregation and Modulating Factors; Katerina E. Paleologou and Omar M. A. El-Agnaf7. Pathological Self-aggregation of β2-microglobulin: A Challenge for Protein Biophysics; Gennaro Esposito, Alessandra Corazza, and Vittorio Bellotti8. Islet amyloid polypeptide – Aggregation and fibrillogenesis in vitro and its Inhibition; Janine Seeliger and Roland Winter9. Mechanisms of Transthyretin Aggregation and Toxicity; Robert J. Gasperini, David W. Klaver, Xu Hou, Marie-Isabel Aguilar and David H. Small10. Fibrillogenesis of Huntingtin and Other Glutamine Containing Proteins; Yuri L. Lyubchenko, Alexey V. Krasnoslobodtsev and Sorin Luca11. Aggregation and Fibrillogenesis of Proteins not Associated with Disease – A few Case Studies; Moritz Lassé, Juliet A. Gerrard and  F. Grant Pearce12. Experimental Inhibition of Peptide Fibrillogenesis by Synthetic Peptides, Carbohydrates and Drugs; Alagiri Srinivasan13. Experimental inhibition of fibrillogenesis and neurotoxicity by amyloid-beta (Aβ) and other disease-related peptides/proteins by plant extracts and herbal compounds; Suresh Kumar, Edward  Okello and J. Robin HarrisIII. Clinical Science: The Cerebral and Systemic Amyloid DiseasesPathogenesis and therapeutic consideration of the major disorders14. Alzheimer’s  Disease; Vanessa J. De-Paula, Marcia Radanovic, Breno S. Diniz, Orestes V. Forlenza15. Modeling the Polyglutamine Aggregation Pathway in Huntington’s Disease: from Basic Studies to Clinical Applications; Keizo Sugaya16. Parkinson’s Disease; Timothy R. Mhyre, James T. Boyd, Robert W.  Hamill, and Kathleen Maguire-Zeiss17. Human Prion Diseases: From Kuru to Variant Creutzfeldt-Jakob Diseasae; Beata Sikorska and Paweł P. Liberski18. Animal Prion Diseases; Otto Windl and Mike Dawson19. β2-microglobulin Amyloidosis; Dorthe B. Corlin and Niels H.H. Heegaard20. Systemic AA Amyloidosis; Jennifer H Pinney and Helen J Lachmann21. Familial Amyloidotic Polyneuropathy and Transthyretin; Takamura Nagasaka 22. The Challenge of Systemic Immunoglobulin Light-chain Amyloidosis (AL); Giovanni Palladini and Raymond L Comenzo