Tumor Dormancy, Quiescence, and Senescence, Volume 1

Preface.-I. Tumor dormancy.- Is tumor dormancy clinically relevant?- Microenvironmental influence on breast cancer Dormancy and metastasis.- Determination of breast cancer dormancy: analysis of Circulating free dna using snp 6.0 arrays.- Clonogenicity of cultured prostate cancer cells is controlled by dormancy : significance and comparison with cell culture models of breast cancer cell dormancy.- Dormancy and metastasis of melanoma cells to lymph Nodes, lung, and liver.- Late recurrence is a sign of melanoma dormancy: need of Life-long follow-up of elanoma patients. II. Quiescence.- Hematopoietic stem cell quiescence and long term Maintenance: role of scl/tal1.- Regulation of muscle stem cell quiescent and Undifferentiated state: roles of hesr1 and hesr3 genes.- The kinase mirk/dyrk1b mediates a reversible quiescent State in a subset of ovarian, pancreatic, and colon cancers. III. Cellular senescence.- Stress -induced senescence: molecular pathways.-11 Accumulation of reactive oxygen species and induction Of premature senescence: role of ddb2.- P21 mediates senescence by a mechanism involving accumulation of reactive oxygen species.- Role of micrornase and zeb1 downmodulation in oxidative  Stress-induced apoptosis and senescence.- Hypoxic response in senescent brain is impaired: possible  Contribution to neurodegeneration.-Enhancing reprogramming to pluripotency by controlling senescence.- Histone deacetylase inhibitor induces replicative Senescence of mesenchymal stem cells.- Senescence arrest of endopolyploid cells renders Senescence into one mechanism for positive tumorigenesis.- The two faces of senescence-associated epigenetic Alterations: tumor suppressors and oncogenic drivers.- Chemotherapy- and radiation-induced accelerated senescence: implications for treatment response, tumor progression, and cancer survivorship.- Suppression of cellular senescence in glioblastoma: role Of src homology domain-containing phosphatase 2.- Chemotherapy ofmalignant pleural mesothelioma induces both senescence and apoptosis.- Microrna as a modulator of cell proliferation and Senescence: role in lung cancer cells.- Role of senescence induction in cancer therapy .- Cellular senescence limits the extent of fibrosis Following liver damage.- Formation of secretory senescent cells in prostate tumors: the role of androgen receptor activity and cell cycle regulation.-Index