Sleep and Anesthesia -

Sleep and Anesthesia (eBook)

Neural Correlates in Theory and Experiment

Axel Hutt (Herausgeber)

eBook Download: PDF
2011 | 2011
XVI, 260 Seiten
Springer New York (Verlag)
978-1-4614-0173-5 (ISBN)
Systemvoraussetzungen
234,33 inkl. MwSt
  • Download sofort lieferbar
  • Zahlungsarten anzeigen

Sleep and anesthesia resemble in many ways at a first glance. The most prominent common feature of course is the loss of consciousness, i.e. the loss of awareness of external stimuli. However a closer look at the loss of consciousness reveals already a difference between sleep and anesthesia: anesthesia is induced by an anesthetic drug whereas we may fall asleep without external cause. Other questions may arise about the difference of the two effects: do we dream during surgery under anesthesia, do we feel pain during sleep? Essentially, we may ask: what is common and what are the differences between sleep and anesthesia? To answer these questions, we may take a look at the neural origin of both effects and the involved physiological pathways. In which way do they resemble? Moreover, we ask what are the detailed features of normal sleep and general anesthesia as applied during surgery and which features exist in both phenomena? If yes in which way?

To receive answers to these questions, it is necessary to consider several experimental techniques that reveal underlying neural mechanisms of sleep and anesthesia. Moreover, theoretical models of neural activity may model both phenomena and comes up with predictions or even theories on the underlying mechanisms. Such models may attack several different description levels, from the microscopic level of single neurons to the macroscopic level of neural populations. Such models may give deeper insight into the phenomena if their assumptions are based on experimental findings and their predictions can be compared to experimental results. This comparison step is essential for valuable theoretical models.

The book is motivated by two successful workshops on anesthesia and sleep organized

during the Computational Neuroscience Conferences in Toronto in 2007 and in Berlin 2009. It aims to cover all the previous aspects with a focus on the link to experimental findings. It elucidates important issues in theoretical models that at the same time reflect some current major research interests. Moreover it considers some diverse issues which are very important to get an overview of the fields. For instance, the book discusses not only neural activity in the brain but also the effects of general anesthesia on the cardio-vascular system and the spinal cord in the context of analgesia. In addition, it considers different experimental techniques on various spatial scales, such as fMRI and EEG-experiments on the macroscopic scale and single neuron and LFP-measurements on the microscopic scale.

In total all book chapters reveal aspects of the neural correlates of sleep and anesthesia motivated by experimental data. This focus on the neural mechanism in the light of experimental data is the common feature of the topics and the chapters. In addition, the book aims to clarify the shared physiological mechanisms of both phenomena, but also reveal their physiological differences.


Sleep and anesthesia resemble in many ways at a first glance. The most prominent common feature of course is the loss of consciousness, i.e. the loss of awareness of external stimuli. However a closer look at the loss of consciousness reveals already a difference between sleep and anesthesia: anesthesia is induced by an anesthetic drug whereas we may fall asleep without external cause. Other questions may arise about the difference of the two effects: do we dream during surgery under anesthesia, do we feel pain during sleep? Essentially, we may ask: what is common and what are the differences between sleep and anesthesia? To answer these questions, we may take a look at the neural origin of both effects and the involved physiological pathways. In which way do they resemble? Moreover, we ask what are the detailed features of normal sleep and general anesthesia as applied during surgery and which features exist in both phenomena? If yes in which way?To receive answers to these questions, it is necessary to consider several experimental techniques that reveal underlying neural mechanisms of sleep and anesthesia. Moreover, theoretical models of neural activity may model both phenomena and comes up with predictions or even theories on the underlying mechanisms. Such models may attack several different description levels, from the microscopic level of single neurons to the macroscopic level of neural populations. Such models may give deeper insight into the phenomena if their assumptions are based on experimental findings and their predictions can be compared to experimental results. This comparison step is essential for valuable theoretical models.The book is motivated by two successful workshops on anesthesia and sleep organized during the Computational Neuroscience Conferences in Toronto in 2007 and in Berlin 2009. It aims to cover all the previous aspects with a focus on the link to experimental findings. It elucidates important issues in theoretical models that at the same time reflect some current major research interests. Moreover it considers some diverse issues which are very important to get an overview of the fields. For instance, the book discusses not only neural activity in the brain but also the effects of general anesthesia on the cardio-vascular system and the spinal cord in the context of analgesia. In addition, it considers different experimental techniques on various spatial scales, such as fMRI and EEG-experiments on the macroscopic scale and single neuron and LFP-measurements on the microscopic scale.In total all book chapters reveal aspects of the neural correlates of sleep and anesthesia motivated by experimental data. This focus on the neural mechanism in the light of experimental data is the common feature of the topics and the chapters. In addition, the book aims to clarify the shared physiological mechanisms of both phenomena, but also reveal their physiological differences.

Foreword: Computing the mindby Anthony Hudetz Preface by Axel Hutt  1. Sleep and Anesthesia: A Consideration of States, Traits, and Mechanismsby G. Mashour, University of Michigan 2. Modelling sleep and general anaesthesiaby J. Sleigh, University of Auckland Section 1: Sleep-------------3. Quantitative Modeling of Sleep Dynamicsby P. Robinson, University of Sydney 4. The fine structure of slow-wave sleep oscillations: from single neurons to large networksby A. Destexhe, CNRS Gif-sur-Yvette Paris 5. A population network model of neuronal and neurotransmitter interactions regulating sleep-wake behavior in rodent speciesby V. Booth, University of Michigan 6. Neural correlates of human NREM sleep oscillationsby P. Maquet, University of Liege Section 2: Anesthesia------------------7. A mesoscopic modelling approach to anaesthetic action on brain electrical activityby D. Liley, Swinburne University of Technology 8. Progress in modeling EEG effects of general anesthesia: Biphasic response and hysteresisby A. Steyn-Ross, University of Waikato 9. EEG modeling in anesthesia: a new insight into mean-field approach for Delta activity generationby Behnam Molaee-Ardekani, University of Rennes 10. A neural population model of the bi-phasic EEG-power spectrum during general anaesthesiaby A. Hutt, INRIA Nancy 11. In vivo-electrophysiology of anesthetic actionby B. Rehberg-Kluge,  Charite Humboldt University Berlin 

Erscheint lt. Verlag 12.7.2011
Reihe/Serie Springer Series in Computational Neuroscience
Springer Series in Computational Neuroscience
Zusatzinfo XVI, 260 p.
Verlagsort New York
Sprache englisch
Themenwelt Mathematik / Informatik Informatik
Medizin / Pharmazie Medizinische Fachgebiete Anästhesie
Medizin / Pharmazie Medizinische Fachgebiete Neurologie
Medizin / Pharmazie Studium
Naturwissenschaften Biologie Humanbiologie
Naturwissenschaften Biologie Zoologie
Schlagworte brain electical activity • sleep dynamics • sleep oscillations • sleep-wake behavior
ISBN-10 1-4614-0173-9 / 1461401739
ISBN-13 978-1-4614-0173-5 / 9781461401735
Haben Sie eine Frage zum Produkt?
PDFPDF (Wasserzeichen)
Größe: 14,5 MB

DRM: Digitales Wasserzeichen
Dieses eBook enthält ein digitales Wasser­zeichen und ist damit für Sie persona­lisiert. Bei einer missbräuch­lichen Weiter­gabe des eBooks an Dritte ist eine Rück­ver­folgung an die Quelle möglich.

Dateiformat: PDF (Portable Document Format)
Mit einem festen Seiten­layout eignet sich die PDF besonders für Fach­bücher mit Spalten, Tabellen und Abbild­ungen. Eine PDF kann auf fast allen Geräten ange­zeigt werden, ist aber für kleine Displays (Smart­phone, eReader) nur einge­schränkt geeignet.

Systemvoraussetzungen:
PC/Mac: Mit einem PC oder Mac können Sie dieses eBook lesen. Sie benötigen dafür einen PDF-Viewer - z.B. den Adobe Reader oder Adobe Digital Editions.
eReader: Dieses eBook kann mit (fast) allen eBook-Readern gelesen werden. Mit dem amazon-Kindle ist es aber nicht kompatibel.
Smartphone/Tablet: Egal ob Apple oder Android, dieses eBook können Sie lesen. Sie benötigen dafür einen PDF-Viewer - z.B. die kostenlose Adobe Digital Editions-App.

Zusätzliches Feature: Online Lesen
Dieses eBook können Sie zusätzlich zum Download auch online im Webbrowser lesen.

Buying eBooks from abroad
For tax law reasons we can sell eBooks just within Germany and Switzerland. Regrettably we cannot fulfill eBook-orders from other countries.

Mehr entdecken
aus dem Bereich

von Reinhard Larsen; Thorsten Annecke

eBook Download (2022)
Urban & Fischer Verlag - Fachbücher
219,99
Struktur und Funktion

von Martin Trepel

eBook Download (2021)
Urban & Fischer Verlag - Lehrbücher
43,99
Grundlagen, Formen der Allgemeinanästhesie, Lokal- und …

von Hans Walter Striebel

eBook Download (2019)
Thieme (Verlag)
349,99