Phagocytosis: The Host -

Phagocytosis: The Host (eBook)

S. Gordon (Herausgeber)

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1999 | 1. Auflage
521 Seiten
Elsevier Science (Verlag)
978-0-08-052610-2 (ISBN)
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An accompanying volume (Volume 6) in this series presents strategies of cellular invasion from the viewpoint of the microbe.
This filed of study is growing rapidly after a somewhat slow start over recent decades. This collection of invited chapters attempts to reflect current research, and brings together cell biologists, microbiologists and immunologists with disparate interests. However, there is a certain unity, even repetition of key themes, hopefully like a symphony rather than a boring catalogue. It will be evident that editorial bias favors intracellular paratism and medically important organisms. The neutrophil is far more than a supporting player to the macrophage, and some attempt is made to remind the reader of some of its unique skills. To retain a manageable size, the emphasis is on relatively early events such as mutual recognition, cell entry, and response, rather than on longterm changes in gene expression by either host cell or pathogen. Viruses are excluded not because of lack of importance but because of somewhat different research approaches, although it is cytogenes, share common strategies in invasion and intercellular spread.

An accompanying volume (Volume 6) in this series presents strategies of cellular invasion from the viewpoint of the microbe.This filed of study is growing rapidly after a somewhat slow start over recent decades. This collection of invited chapters attempts to reflect current research, and brings together cell biologists, microbiologists and immunologists with disparate interests. However, there is a certain unity, even repetition of key themes, hopefully like a symphony rather than a boring catalogue. It will be evident that editorial bias favors intracellular paratism and medically important organisms. The neutrophil is far more than a supporting player to the macrophage, and some attempt is made to remind the reader of some of its unique skills. To retain a manageable size, the emphasis is on relatively early events such as mutual recognition, cell entry, and response, rather than on longterm changes in gene expression by either host cell or pathogen. Viruses are excluded not because of lack of importance but because of somewhat different research approaches, although it is cytogenes, share common strategies in invasion and intercellular spread.

Cover 1
CONTENTS 6
LIST OF CONTRIBUTORS 10
INTRODUCTION TO THE SERIES 16
PREFACE 18
SECTION I: CONTEXT 22
CHAPTER 1. THE EARLY HISTORY OF PHAGOCYTOSIS 24
CHAPTER 2. DROSOPHILA HEMOCYTES, PHAGOCYTOSIS, AND CROQUEMORT, A MACROPHAGE RECEPTOR 40
CHAPTER 3. PHAGOCYTOSIS BY NONPROFESSIONAL PHAGOCYTES 68
SECTION II: RECEPTORS 90
CHAPTER 4. SCAVENGER RECEPTORS AND PHAGOCYTOSIS OF BACTERIA AND APOPTOTIC CELLS 92
CHAPTER 5. MANNOSE RECEPTOR AND PHAGOCYTOSIS 108
CHAPTER 6. INTEGRIN RECEPTORS OF PHAGOCYTES 124
CHAPTER 7. FC RECEPTOR–MEDIATED PHAGOCYTOSIS 170
SECTION III: SIGNALING 214
CHAPTER 8. HETEROGENEITY IN MACROPHAGE PHAGOCYTOSIS 216
CHAPTER 9. SIGNALING THROUGH RHO GTPASES IN PHAGOCYTES 236
CHAPTER 10. REGULATORY ROLES OF PHOSPHATIDYLINOSITOL (4,5) BISPHOSPHATE IN CELL SIGNALING, MEMBRANE TRAFFIC, AND THE CYTOSKELETON 254
SECTION IV: THE PATHWAY 286
CHAPTER 11. PATHWAYS THROUGH THE MACROPHAGE VACUOLAR COMPARTMENT 288
CHAPTER 12. SEQUENTIAL MATURATION OF PHAGOSOMES PROVIDES UNIQUE TARGETS FOR PATHOGENS 306
CHAPTER 13. PHAGOSOMAL ACIDIFICATION: MECHANISMS AND FUNCTIONAL SIGNIFICANCE 320
CHAPTER 14. THE PHAGOCYTE ACTIN CYTOSKELETON 342
SECTION V: RESPONSES 364
CHAPTER 15. NRAMP1 A NOVEL MACROPHAGE PROTEIN WITH A KEY FUNCTION IN RESISTANCE TO INTRACELLULAR PATHOGENS 366
CHAPTER 16. UPTAKE AND PRESENTATION OF PHAGOCYTOSED ANTIGENS BY DENDRITIC CELLS 384
CHAPTER 17. PROCESSING AND PRESENTATION OF PHAGOCYTOSED ANTIGENS TO THE IMMUNE SYSTEM 400
CHAPTER 18. ANTIMICROBIAL MECHANISMS OF MACROPHAGES 428
CHAPTER 19. COMPONENTS AND ORGANIZATION OF THE NADPH OXIDASE OF PHAGOCYTIC CELLS: ITS ROLE IN MICROBIAL KILLING AND IN THE MOLECULAR PATHOLOGY OF CHRONIC GRANULOMATOUS DISEASE 462
CHAPTER 20. OXYGEN-INDEPENDENT ANTIMICROBIAL MECHANISMS OF PMN 506
INDEX 534

Erscheint lt. Verlag 22.11.1999
Sprache englisch
Themenwelt Naturwissenschaften Biologie Biochemie
Naturwissenschaften Biologie Genetik / Molekularbiologie
Naturwissenschaften Biologie Zellbiologie
Naturwissenschaften Physik / Astronomie Angewandte Physik
Technik
ISBN-10 0-08-052610-1 / 0080526101
ISBN-13 978-0-08-052610-2 / 9780080526102
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