International Review of Cytology (eBook)

Cover 1
Contents 6
Contributors 9
Pathophysiological Dynamics of Human Ovarian Surface Epithelial Cells in Epithelial Ovarian Carcinogenesis 11
I. Introduction 1 12
II. Characteristics and Properties of Human Ovarian Surface Epithelial Cells 13
III. Biology and Molecular Pathology of Normal Human Ovarian Surface Epithelial Cells and Epithelial Ovarian Cancer Cells 28
IV. Cell Culture and In Vitro Tumorigenicity of Human Ovarian Surface Epithelial Cells 41
V. Conclusions and Perspectives 49
Morphodynamics of the Secretory Pathway 65
I. Introduction 2 66
II. Morphodynamics of the Secretory Pathway 69
III. Structure of the Golgi Apparatus and Functional Hypotheses 94
IV. Molecular Dynamics Supporting Morphogenesis: Examples from Yeast and Animal Cells 98
V. Formal Models 110
VI. Concluding Remarks 112
Aspects of Collagen Mineralization in Hard Tissue Formation 131
I. Introduction 3 131
II. Collagens 132
III. Mineral Matrix Relationship 141
IV. Mineral Nucleation and Maturation 147
V. Concluding Remarks 158
The Hypoxia-Inducible Factor and Tumor Progression Along the Angiogenic Pathway 167
I. Introduction 4 167
II. The General Function, Mechanistics, and Structure of the bHLH-PAS Domain Family of Proteins 168
III. Regulation of HIF 175
IV. The Biological Roles of HIF 193
V. The Role of HIF in Tumorigenesis and Therapy 200
VII. Concluding Remarks 204
Multidrug Resistance in Yeast 224
I. Introduction 5 224
II. Resistance to Antifungals 225
III. Concluding Remarks 249
Intercellular Coupling of Interstitial Cells of Cajal in the Digestive Tract* 258
I. Introduction 6 258
II. Morphological Features of ICC Networks 259
III. Functional Features of ICC 266
IV. Communications of ICC with Smooth Muscle Cells 282
V. Clinical Implications of ICC Coupling 285
VI. Conclusions 6 285
Chromatin Organization in the Mammalian Nucleus 292
I. Introduction 7 292
II. Components of the Chromatin Fiber 293
III. Interphase Chromosomes 310
IV. Nuclear Structure and Processes 321
V. Concluding Remarks 7 327
Index 346