Thiamine Deficiency and Associated Clinical Disorders (eBook)

Preface 5
Acknowledgments 9
Contents 10
Early Chemistry 12
Early Thiamine Deficiency 19
Thiamine Deficiency in Mammals 27
Beriberi 41
Wernickes Disease 57
Central Pontine Myelinolysis, Alcoholic Cerebellar Degeneration, and MarchiafavaBignami Disease 75
Central Pontine Myelinolysis 75
Alcoholic Cerebellar Degeneration 81
MarchiafavaBignami Disease 85
Leighs Disease 91
African Seasonal Ataxia 112
Inherited Ataxias 122
Thiamine Deficiency in Serious Illness 139
Beriberi 139
Cancer 140
Intensive Care Units 141
Hematologic Tumors 142
Gastrectomy 142
5-Fluorouracil 144
Wernickes Disease and Gastrectomy 147
HIV/AIDS 147
Malaria 149
Amyotrophic Lateral Sclerosis 150
Alzheimers Disease 150
World Health Concerns 152
Epilogue: Future Prospects 157
Animal Models of Thiamine Deficiency 157
Beriberi 159
Wernickes Disease 160
CPM/ACD/MBD 162
Leighs Disease 163
Inherited Ataxias 164
Serious Illnesses and Thiamine Deficiency 165
Conclusions 166
Antineuritic Vitamin and Beriberi 165
Appendix A Bontius Translation 167
Appendix B Thiamine Synonyms 168
Appendix C The Nobel Prize Acceptance Speechof Dr. Christiaan Eijkman, 1929 169
References 176
Index 187