Biophysical Aspects of Transmembrane Signaling (eBook)

Sándor Damjanovich initially studied medicine, and after he obtained his MD, he reoriented his focus in sciences and studied physics. After obtaining his three degrees (MD, Ph.D. and D.Sc) in Hungary, he travelled around the world studying and doing research in spectroscopy of proteins, molecular and cell biology of transmembrane signalling, and different aspects of membrane biophysics. While most of the time he preferentially applied luminescence methods, he also used other methods of investigation including flow cytometry, resonance energy transfer, steady state and time resolved fluorescence and phosphorescence spectroscopy, and most recently scanning force microscopy and near field optical microscopy in order to study cell surface phenomena. He and his co-workers have described a number of molecular patterns at the membrane of lymphocytes and other cells and are proponents of the belief that dynamic cell surface patterns and receptor superstructures govern immune processes and pharmacological interactions at the plasma membrane. As a recipient of several major fellowships and visiting professorships, he has spent more than two years at the Max Planck Institute for Biophysical Chemistry in Göttingen, Germany, as well as extended visits in the United States (NIH, FDA and at the University of California in San Francisco). He is a member of the Hungarian Academy Sciences (currently the President of the Department of Biology of the Academy) and is also a member of EMBO. He has received many awards including the Széchenyi Prize and the Szilárd Leó Professorial Stipend. He is the author of over 250 publications and several books, among others on Mobility and Proximity of Macromolecules in Biological Membranes (CRC Press). Sándor DAMJANOVICH has been a Full Professor in the Department of Biophysics and Cell Biology, University of Debrecen, Hungary, since 1972.

Preface 5
Contents 6
List of Contributors 13
The Impact of Environmental Signals on the Growth and Survival of Human T Cells 17
Novel Single Cell Fluorescence Approaches in the Investigation of Signaling at the Cellular Level 49
Non- Random Patterns of Membrane Proteins and Their Roles in Transmembrane Signaling 87
Transmembrane Signals Mediated by IL- 2 and IL- 15 Control the Life and Death of Lymphocytes 113
Single- Molecule Imaging of Diffusion, Recruitment, and Activation of Signaling Molecules in Living Cells 139
Chemokine Signaling: The Functional Importance of Stabilizing Receptor Conformations 169
Signaling and Reverse Signaling in the Tumor Necrosis Factor/ TNF Receptor System 187
Regulation of Immunoreceptor Activities: The Paradigm of the Type I Fce Receptor 227
Histamine Receptors and Signaling 281
Signal Transduction by Ion Channels in Lymphocytes 309
Subject Index 333