Signal Transduction in the Cardiovascular System in Health and Disease (eBook)

Preface 6
Contents 9
Contributors 12
Part I G-protein-Coupled Receptor Signaling 18
Chapter 1 Implication of G-proteins in Cardiovascular Disease 19
Chapter 2 ß-Adrenoceptor-Linked Signal Transduction Mechanisms in Congestive Heart Failure 43
Chapter 3 Cardiac G as and G ai Modulate Sympathetic Versus Parasympathetic Mechanisms in Hyperhomocysteinemia 66
Chapter 4 The Role of the Beta-Adrenergic Signal Transduction Pathway in Myocardial Protection 82
Chapter 5 Angiotensin II Signaling in Vascular Physiology and Pathophysiology 103
Chapter 6 Angiotensin II Signaling: Cell Growth and Apoptosis 130
Part II Redox Signaling 151
Chapter 7 Thioredoxin Signaling in the Ischemic Heart 152
Chapter 8 Relationship Between Redox Regulation and ß-Adrenergic Responses in the Heart 167
Chapter 9 Role of Hyperglycemia and Redox-Induced Signaling in Vascular Complications of Diabetes 187
Chapter 10 Methylglyoxal and Insulin Resistance 203
Part III Growth Factor Signaling 219
Chapter 11 Role of Growth Factor Receptor Transactivation in Vasoactive Peptide-Induced Signaling Pathways in Vascular Smooth Muscle Cells 220
Chapter 12 Identifying the Cellular and Molecular Events Associated with the Divergent Phenotypes of Cardiac Hypertrophy 238
Chapter 13 Regulatory Role of TGF-ß in Cardiac Myofibroblast Function and Post-MI Cardiac Fibrosis: Key Roles of Smad7 and c-Ski 257
Chapter 14 The Signaling Duel Between Virus and Host: Impact on Coxsackieviral Pathogenesis 275
Chapter 15 Therapeutic Angiogenesis and Vasculogenesis for Ischemic Disease 293
Chapter 16 VEGF Signaling: A Therapeutic Target for Cardiovascular Disease 308
Chapter 17 Myristoyl-CoA: Protein N-Myristoyltransferase and Myristoyl-CoA Binding Protein from Bovine Cardiac Muscle 334
Part IV Calcium Signaling 343
Chapter 18 Ca2+ / Calmodulin-Dependent Protein Kinase II Signaling in Vascular Smooth Muscle 344
Chapter 19 The KCa3.1 Channel in Endothelial Cells as New Target for an EDHF-Based Control of Vascular Tone: From Structure to Regulation and Pharmacological Properties 361
Part V Adipokine Signaling 379
Chapter 20 Leptin Signaling in the Cardiovascular System 380
Chapter 21 AMPK Regulation of Cardiac Metabolism in Heart Disease 399
Signal Transduction in the Cardiovascular System in Health and Disease 413
Index 415