The Leydig Cell in Health and Disease (eBook)

PREFACE 6
CONTENTS 8
CONTRIBUTORS 10
LIST OF COLOR IMAGES 12
I HISTORICAL 14
1 A History of Leydig Cell Research 15
II CELL BIOLOGY 43
2 Structural and Histological Analysis of Leydig Cell Steroidogenic Function 44
3 Fetal Leydig Cells 57
4 Regulation of Leydig Cells During Pubertal Development 65
5 The Human Leydig Cell 81
6 Dynamics of Leydig Cell Regeneration After EDS 100
7 Aging and the Decline of Androgen Production 126
III STEROIDOGENESIS 141
8 Regulation of Leydig Cell Cholesterol Metabolism 142
9 The Role of StAR in Leydig Cell Steroidogenesis 156
10 Steroidogenic Enzymes in Leydig Cells 163
11 Development of Leydig Cell Steroidogenesis 178
12 Peripheral Testosterone Metabolism 185
13 Leydig Cell Aromatase 193
14 The Role of Estrogen Sulfotransferase in Leydig Cells 200
15 Endocrinology of Leydig Cells in Nonmammalian Vertebrates 209
IV REGULATION 227
16 The Luteinizing Hormone Receptor 228
17 Insights Into Leydig Cell Function From Mice With Genetically Modified Gonadotropin Action 254
18 Growth Factors in Leydig Cell Function 263
19 Insulin-Like Peptide 3 in Leydig Cells 278
20 Neuronal Signaling Molecules and Leydig Cells 289
21 Regulation of Leydig Cell Function as it Pertains to the Inflammatory Response 303
22 Activins and Leydig Cell Development, Differentiation, and Disease 320
23 Transcription Factors as Regulators of Gene Expression During Leydig Cell Differentiation and Function 329
24 Androgen Receptor in Leydig Cell Function and Development 340
V PHYSIOLOGY AND APPLIED ASPECTS 358
25 Fluid Exchange and Transport of Hydrophilic Factors in the Testis 359
26 Immortalized Leydig Cell Lines as Models for Studying Leydig Cell Physiology 367
27 Induction of Leydig Cell Tumors by Xenobiotics 376
28 Environmental Factors That Disrupt Leydig Cell Steroidogenesis 386
29 The Leydig Cell as a Target for Male Contraception 407
30 Clinical Evaluation of Leydig Cell Function 435
INDEX 459