The Zebrafish: Disease Models and Chemical Screens

Professor of Biochemistry and Marine Biology at Northeastern University, promoted 1996. Joined Northeastern faculty in 1987. Previously a faculty member in Dept. of Biochemistry at the University of Mississippi Medical Center, 1983-1987.Principal Investigator in the U.S. Antarctic Program since 1984. Twelve field seasons "on the ice" since 1981. Research conducted at Palmer Station, Antarctica, and McMurdo Station, Antarctica.Research areas: Biochemical, cellular, and physiological adaptation to low and high temperatures. Structure and function of cytoplasmic microtubules and microtubule-dependent motors from cold-adapted Antarctic fishes. Regulation of tubulin and globin gene expression in zebrafish and Antarctic fishes. Role of microtubules in morphogenesis of the zebrafish embryo. Developmental hemapoiesis in zebrafish and Antarctic fishes. UV-induced DNA damage and repair in Antarctic marine organisms.

Part I: Disease Models 1. Germ Cell Tumors in Zebrafish 2. Schwann Cell Myelination Mutants as Models of Multiple Sclerosis 3. In Vivo Analysis of Zebrafish Adipogenesis 4. Host-Microbe Interactions in the Zebrafish 5. Hematopoietic Stem Cell Development and Blood Flow 6. Zebrafish as a Model for Hemorrhagic Stroke 7. Zebrafish Adaptive Immunity: Structure and Function of Physiologic Development and Malignant Transformation 8. Zebrafish VHL Disease Model 9. Muscle Diseases 10. Basement Membrane Diseases 11. Lymphangiogenesi 12. Osteogenesis 13. Zebrafish Assays of Ciliopathies 14. Infectious Disease: Innate Immunity 15. Tuberculosis 16. Cancer 17. Melanoma 18. Pancreatic Cancer 19. Rhabdomyosarcoma 20. Transplantation in Zebrafish 21. Modeling Human Disease by Gene Targeting 22. Fluorescent Imaging of Cancer 23. Zebrafish as a Model for Fanconi’s Anemia

Part II: Chemical Screens 24. Chemical Screens for Potential Therapeutics 25. Psychotropic Drug Discovery by Automated Behavioral Phenotyping 26. Discovery and Use of Small Molecules for Probing Biological Processes