Chromosomal Mutagenesis

Biallelic Gene Knockouts in Chinese Hamster Ovary Cells.- Highly Proficient Gene Targeting by Homologous Recombination in the Human Pre-B Cell Line Nalm-6.- Robust Cell Line Development Using Meganucleases.- Design and Testing of Zinc Finger Nucleases for Use in Mammalian Cells.- Gene Targeting in Drosophila and Caenorhabditis elegans With Zinc-Finger Nucleases.- Orpheus Recombination.- Transposon-Mediated Mutagenesis in Somatic Cells.- Insertional Mutagenesis of the Mouse Germline With Sleeping Beauty Transposition.- Conditional Gene Trapping Using the FLEx System.- Steps Toward Targeted Insertional Mutagenesis With Class II Transposable Elements.- Targeting Integration of the Saccharomyces Ty5 Retrotransposon.- Site-Specific Chromosomal Integration Mediated by ?C31 Integrase.- Triplex-Mediated Gene Modification.- Allelic Exchange of Unmarked Mutations in Mycobacterium Tuberculosis.- Mycobacterial Recombineering.- Chromosomal Engineering of Clostridium Perfringens Using Group II Introns.