Chromatin and Gene Regulation - Bryan M. Turner

Chromatin and Gene Regulation

Molecular Mechanisms in Epigenetics

(Autor)

Buch | Softcover
304 Seiten
2001
Wiley-Blackwell (Verlag)
978-0-86542-743-3 (ISBN)
103,70 inkl. MwSt
* Explains the fundamental concept of what makes a cell different from another in simple terms in this exciting and rapidly developing area of modern biology. * Includes a colour plate section. * An up--to--date and essential new textbook which will compliment Whitea s Gene Transcription: Mechanisms and Control.
Written in an informal and accessible style, Chromatin and Gene Regulation enables the reader to understand the science of this rapidly moving field. Chromatin is a fundamental component in the network of controls that regulates gene expression. Many human diseases have been linked to disruption of these control processes by genetic or environmental factors, and unravelling the mechanisms by which they operate is one of the most exciting and rapidly developing areas of modern biology. Chromatin is central both to the rapid changes in gene transcription by which cells respond to changes in their environment and also to the maintenance of gene expression patterns from one cell generation to the next. This book will be an invaluable guide to undergraduate and postgraduate students in the biological sciences and all those with an interest in the medical implications of aberrant gene expression.

Bryan M. Turner is Professor of Experimental Genetics at School of Cancer Sciences, Institute of Biomedical Research, University of Birmingham in Birmingham, UK. He was educated at University College London, where he earned his BSc in Biochemistry and PhD in Human Biochemical Genetics.

Prologue. .

1. Controlling transcription: shared aims and common mechanisms.

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2. Transcription in eukaryotes: the problems of complexity.

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3. The nucleosome: chromatin's structural unit.

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4. Histone tails: modifications and epigenetic information.

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5. Higher-order chromatin structures and nuclear organisation.

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6. Transcription in a chromatin environment.

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7. How the transcription machinery deals with chromatin.

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8. Chromatin remodelling machines.

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9. Heterochromatin.

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10. Long-term silencing of gene expression.

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11. Cellular memory and imprinting.

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12. Mechanisms of dosage compensation

Erscheint lt. Verlag 19.12.2001
Verlagsort Hoboken
Sprache englisch
Maße 173 x 245 mm
Gewicht 644 g
Themenwelt Naturwissenschaften Biologie Allgemeines / Lexika
Naturwissenschaften Biologie Genetik / Molekularbiologie
Naturwissenschaften Biologie Zellbiologie
ISBN-10 0-86542-743-7 / 0865427437
ISBN-13 978-0-86542-743-3 / 9780865427433
Zustand Neuware
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