Dopamine Handbook

Leslie L. Iversen, PhD, is Professor of Pharmacology at the University of Oxford, Oxford. Susan D. Iversen, PhD, is a Professor in the Department of Experimental Psychology at the University of Oxford, Oxford, UK Stephen B. Dunnett, PhD is a Professor in the School of Biosciences at Cardiff University, Cardiff, Wales, UK. Anders Björklund, MD, PhD, is a Professor at the Wallenberg Neuroscience Center Division of Neurobiology at Lund University in Lund, Sweden

Contributors

Chapter 1: Overview: A Personal View of the Dopamine Neuron in Historical Perspective

Floyd E. Bloom

Chapter 2: Neuroanatomy

2.1. Functional Neuroanatomy of Dopamine in the Striatum

Charles R. Gerfen

2.2. Functional Implications of Dopamine D2 Receptor Localization in Relation to Glutamate

Neurons

Susan R. Sesack

2.3. Convergence of Limbic, Cognitive and Motor Cortico-striatal Circuits with Dopamine Pathways in Primate

Brain

Suzanne N. Haber

2.4. The Relationship between Dopaminergic Axons and Glutamatergic Synapses in the Striatum: Structural

Considerations.

J. Paul Bolam and Jonathan Moss

Chapter 3: Molecular Pharmacology

3.1. Molecular Pharmacology of the Dopamine Receptors

David R. Sibley, Michele L. Rankin, Lisa A. Hazelwood, R. Benjamin Free, Yoon Namkung, Elizabeth B. Rex,

and Rebecca A. Roof

3.2. Role of Dopamine Transporters in Neuronal Homeostasis

Marc G. Caron and Raul R. Gainetdinov

3.3. Intracellular Dopamine Signaling

Gilberto Fisone

3.4. Ion Channels & Regulation of Neuronal Activity

Birgit Liss and Jochen Roeper

Chapter 4: Genes in Development

4.1.Genetic Control of Meso-diencephalic Dopaminergic Neuron Developments in Rodents

Wolfgang Wurst and Nilima Prakash

4.2. Factors Shaping Later Stages of Dopamine Neuron Development

Robert E. Burke

4.3. Postnatal Maturation of Dopamine Actions in the Prefrontal Cortex

Patricio O'Donnell and Kuei Y. Tseng

4.4. Genetic Dissection of Dopamine Mediated Prefrontal-Striatal Mechanisms and Its Relationship to

Schizophrenia

Daniel Weinberger and Hao-Yang Tan

Chapter 5: DA in Prefrontal Cortex and Cognition

5.1. From Behavior to Cognition: Functions of Mesostriatal, Mesolimbic and Mesocortical Dopamine Systems

Trevor W. Robbins

5.2. Contributions of Mesocorticolimbic Dopamine to Cognition and Executive Function

Stan B. Floresco

5.3. Dopamine's Influence on Prefrontal Cortical Cognition: Actions and Circuits of Behaving

Primates

Amy F.T. Arnsten, Susheel Vijayraghavan, Min Wang, Nao J. Gamo, and Constantinos D.

Paspalas

5.4. Dopaminergic Modulation of Flexible Cognitive Control in Humans

Mark D'Esposito and Roshan Cools

5.5. Neurocomputational analysis of DA Function

Daniel Durstewitz

Chapter 6: Ventral Striatum and Reward

6.1. Dopamine and Motor Function in Rat and Mouse Models of Parkinson's Disease

Timothy Schallert and Sheila M. Fleming

6.2. Involvement of Nucleus Accumbens Dopamine in Behavioral Activation and Effort-related

Functions

John D. Salamone

6.3. Functional Heterogeneity in Striatal Subregions and Neurotransmitter Systems: Implications

for Understanding the Neural Substrates Underlying Appetitive Motivation and Learning

Brian A. Baldo and Matthew E. Andrzejewski

6.4. Behavioral Functions of Dopamine Neurons

Philippe N. Tobler

Chapter 7: Plasticity of Forebrain DA Systems

7.1. Dynamic Templates for Neuroplasticity in the Striatum

Ann M. Graybiel

7.2. DA and Synaptic Plasticity in Mesolimbic Circuits

Robert C. Malenka, F. Woodward Hopf, and Antonello Bonci

7.3. Dopaminergic Modulation of Striatal Glutamatergic Signaling in Health and Parkinson's

Disease

D. James Surmeier, Michelle Day, Tracy Gertler, Savio Chan, and Weixing Shen

Chapter 8: DA Mechanisms in Addiction

8.1. The Role of Dopamine in the Motivational Vulnerability to Addiction

George F. Koob and Michel Le Moal

8.2. Dopaminergic Mechanisms in Drug Seeking Habits and the Vulnerability to Drug Addiction

Barry J. Everitt, David Belin, Jeffrey W. Dalley, and Trevor W. Robbins

8.3. Imaging Dopamine's Role in Drug Abuse and Addiction

Nora D. Volkow, Joanna S. Fowler, Gene-Jack Wang, Frank Telang, and Ruben Baler

Chapter 9: Parkinson's disease

9.1. Exploring the Myths about Parkinson's disease

Yves Agid and Andreas Hartmann

9.2. Pathophysiology of L-DOPA-induced Dyskinesia in Parkinson's disease

M. Angela Cenci

9.3. Progression of Parkinson's disease Revealed by Imaging Studies

David J. Brooks

9.4. Transplantation of Dopamine Neurons: Extent and Mechanisms of Functional Recovery in

Rodent Models of Parkinson's disease

Stephen B. Dunnett and Anders Björklund

9.5. Clinical Experiences with Dopamine Neuron Replacement in Parkinson's disease. What is

the Future?

Olle Lindvall

9.6. Novel Gene-based Therapeutics Targeting the Dopaminergic System in Parkinson's disease

Deniz Kirik, Jeffrey H. Kordower, Shilpa Ramaswamy, and Tomas Björklund

9.7. Neuroprotective Strategies in Parkinson's Disease

C. Warren Olanow

Chapter 10: Schizophrenia and Other Psychiatric Illnesses

10.1. Dopamine Dysfunction in Schizophrenia

Anissa Abi-Dargham, Mark Slifstein, Larry Kegeles, and Marc Laruelle

10.2. Neuropharmacological Profiles of Antipsychotic Drugs

Bryan L. Roth and Sarah C. Rogan

10.3. How Antipsychotics Work-Linking Receptors to Response

Shitij Kapur and Nathalie Ginovart

10.4. Dopamine Dysfunction in Schizophrenia: From Genetic Susceptibility to Cognitive Impairment

Andreas Meyer-Lindenberg, Heike Tost, and Shabnam Hakimi

10.5. The Role of Dopamine in the Pathophysiology and Treatment of Major Depressive Disorder

Charles B. Nemeroff and Boadie W. Dunlop

10.6. DA Modulation of Forebrain Pathways and the Pathophysiology of Psychiatric Disorders

Anthony A. Grace

Index