Evidence–based Hematology

Dr Mark Crowther is Associate Professor of Medicine and Program Director of the Adult Hematology Residency Training Program at McMaster University. He is a member of the Canadian Critical Care Trials Group. Dr. Jeffrey Ginsberg is a leading expert in the diagnosis, prevention and management of venous thromboembolism and has led many of the "practice changing" studies published in this area in the last 20 years. He is the recipient of numerous awards and distinctions, most recently an endowed chair at McMaster University allowing him to pursue further research in venous and arterial thrombosis. Dr. Holger Schunemann is a leading expert in evidence based practice with a particular interest in the development and widespread dissemination of validated evidence scoring criteria. Dr. Schunemann has played an important role in the evolution of evidence based guidelines currently written by organizations such as the American College of Chest Physicians and the American Thoracic Society. Dr. Ralph Meyer has recently joined the National Cancer Institute of Canada after a distinguished career at McMaster University. Dr. Meyer is responsible for administering the Clinical Trial Program at the NCIC. The NCIC has led or participated in many national and international studies which guide current best treatment practices for disorders such as Hodgkin's disease, multiple myeloma and other hematologic malignancies. Dr. Richard Lottenberg is a professor of medicine and past Division Chair of the division of Hematology and Oncology. He is currently the Training Program Director at the University of Florida and is widely regarded as an expert in the evidence based management of sickle cell anemia.

Part 1 A Guide to the Evidence. 1 Rating the Quality of Evidence and Making Recommendations: A Guide to the Spectrum of Clinical Research: Holger J. Schunemann, Martin Stanulla, Jan L. Brozek, Gordon G. Guyatt. 2 An Overview of Systematic Reviews: Martin Prins, Arina ten Cate-Hoek, Pieter Leffers. 3 Interpreting Results in Clinical Research: Overview of measures of effect, measures of precision, and measures of diagnostic accuracy for clinicians and researchers: Marcello Di Nisio, Harry R. Buller, Patrick M. M. Bossuyt. 4 Finding the Evidence in Hematology: K. Ann McKibbon, Cynthia J. Walker-Dilks, R. Brian Haynes. 5 Applying EBM in Clinical Practice: Alessandro Squizzato, Walter Ageno, Davide Imberti. 6 Using Evidence to Guide the Diagnosis of Disease: Lucas M. Bachmann, Holger J. Schunemann . Part 2 Hemostasis and Thrombosis. 7 Diagnosis of Deep Vein Thrombosis: Lori-Ann Linkins. 8 The Diagnosis of Acute Pulmonary Embolism: Victor F. Tapson. 9 Initial Therapy of Deep Vein Thrombosis and Pulmonary Embolism: Sam Schulman. 10 Long-Term Anticoagulation in Venous Thromboembolism: Clive Kearon. 11 Thrombolytic Therapy for Deep Vein Thrombosis and Pulmonary Embolism: Simon J. McRae, John W. Eikelboom. 12 Inferior Vena Cava Interruption: Michael B. Streiff, Christine L. Hann. 13 Management of Venous Thromboembolism in Pregnancy: Wee-Shian Chan. 14 Pediatric Thrombosis: Anthony K. C. Chan, Paul Monagle. 15 Bridging Anticoagulation in PatientsWho Require Temporary Interruption ofWarfarin for Surgery: James D. Douketis, Scott Kaatz. 16 Evidence-based Approach to the Diagnosis and Management of Thrombotic Thrombocytopenic Purpura: Brian Boulmay, Craig S. Kitchens. 17 Diagnosis and Management of Disseminated Intravascular Coagulation: Julia A. M. Anderson. 18 Diagnosis and Management of Hereditary Bleeding Disorders: Including Congenital/Acquired Platelet Function Disorders: Nigel S. Key, Alice D. Ma. 19 Diagnosis and Management of Acquired Bleeding Disorders: Vitamin K Antagonists: Miguel A. Escobar. 20 Diagnosis and Management of Heparin-Induced Thrombocytopenia: Theodore E. Warkentin, Andreas Greinacher. 21 Management of Antiphospholipid Antibody Syndrome: Wendy Lim, Mark A. Crowther . Part 3 Benign Hematologic Disorders. 22 Clinical Questions in Iron Overload: Antonello Pietrangelo, Nicola Magrini. 23 Aplastic Anemia, Paroxysmal Nocturnal Hemoglobinuria, and Pure Red Cell Aplasia: Shivani Srivastava, Richard W. Childs. 24 Acquired Anemias: Iron Deficiency, Cobalamin Deficiency, and Autoimmune Hemolytic Anemia: Marc S. Zumberg, Marc J. Kahn. 25 Immune Thrombocytopenic Purpura: James N. George, Sara K. Vesely, George R. Buchanan. 26 Neutropenia: David C. Dale. 27 Hypereosinophilia: Primary and Secondary: Florence Roufosse, Michel Goldman, Elie Cogan. 28 Porphyrias: Gagan Sood, Karl E. Anderson. 29 Membrane and Enzyme Abnormalities of the Erythrocyte: Patrick G. Gallagher, Ernest Beutler. 30 Sickle Cell Disease: Richard Lottenberg, Sally C. Davies. 31 Evidence-based Treatment of Thalassemia Major: Issac Odame, Deborah Rund . Part 4 Malignant Hematologic Disorders. 32 Acute Lymphoblastic Leukemia in Adults: Stephen Couban, Andrea Kew. 33 Acute Myeloid Leukemia in Adults: Remission: Induction Therapy: Cara A. Rosenbaum, Richard A. Larson. 34 Acute Myeloid Leukemia in Adults: Postremission Therapy: Cara A. Rosenbaum, Richard A. Larson. 35 Current Areas of Controversy in the Treatment of Patients With Newly Diagnosed Acute Promyelocytic Leukemia: Martin S. Tallman, Syed A. Abutalib. 36 Chronic Lymphocytic Leukemia: Bruce D. Cheson. 37 Chronic Myeloid Leukemia: Irwin Walker. 38 Selected Management of Patients with Myelodysplastic Syndromes: John M. Storring, Karen W. L. Yee. 39 Evidence-based Treatment of Burkitt Lymphoma in Adults: John Gerecitano, David J. Straus. 40 Primary Central Nervous System Lymphoma: Tamara Shenkier. 41 Diffuse Large B-cell Lymphoma: Michael Crump. 42 Follicular Lymphoma: Kevin Imrie, Matthew Cheung. 43 Lymphoblastic Lymphoma: Tyler Y. Kang, John W. Sweetenham. 44 Mantle Cell Lymphoma: C. Tom Kouroukis. 45 Management of Patients with Peripheral T-cell Lymphoma: Kerry J. Savage. 46 Selected Management Issues of Patients with Hodgkin Lymphoma: Ralph M. Meyer. 47 Lymphocyte Predominant Hodgkin Lymphoma: Brandon McMahon, Jonathan W. Friedberg. 48 Management of Patients with Essential Thrombocythemia: Guido Finazzi, Giovanni Barosi, Tiziano Barbui. 49 Management of Patients with Polycythemia Vera: Guido Finazzi, Roberto Marchioli, Tiziano Barbui. 50 Evidence-based Review of Therapies in Multiple Myeloma: Michael Sebag, A. Keith Stewart. 51 Management ofWaldenstrom's Macroglobulinemia: Christine I. Chen. 52 The Role of Hematopoietic Growth Factors in Managing Patients with Hematologic Malignancies: Heloisa P. Soares, Ambuj Kumar, Charles Bennett, Benjamin Djulbegovic . Index