Tumor Biomarker Discovery

Identification of Tumor-Associated Antigens as Diagnostic and Predictive Biomarkers in Cancer.- Autoantibodies Against Cancer Antigens.- Discovery of Antibody Biomarkers Using Protein Microarrays of Tumor Antigens Cloned in High Throughput.- Analysis of Glycans on Serum Proteins Using Antibody Microarrays.- Glycoproteomic Analysis by Two-Dimensional Electrophoresis.- All-Liquid Separations, Protein Microarrays, and Mass Spectrometry to Interrogate Serum Proteomes: An Application to Serum Glycoproteomics.- Reverse-Phase Protein Microarrays for Theranostics and Patient Tailored Therapy.- Serum Proteomics Using Mass Spectrometry.- Hormones as Biomarkers: Practical Guide to Utilizing Luminex Technologies for Biomarker Research.- High-Throughput Analysis of Serum Antigens Using Sandwich ELISAs on Microarrays.- Tissue Microarrays as a Tool in the Discovery and Validation of Tumor Markers.- Quantitative, Fluorescence-Based In-Situ Assessment of Protein Expression.- Tumor Marker Discovery by Expression Profiling RNA from Formalin Fixed Paraffin Embedded Tissues.- High-Throughput Mutation Screening Using a Single Amplification Condition.- DNA Sequencing of Cancer-Related Genes for Biomarker Discovery.- Analysis of Loss of Heterozygosity in Circulating DNA.- Pharmacogenomics.- Study Designs in Genetic Epidemiology.- Developing Classifiers for the Detection of Cancer Using Multi-Analytes.- Metabolomics of Cancer.- MRI and MRS of Human Brain Tumors.- Magnetic Resonance Spectroscopy of Living Tissues.

From the reviews:

“This well-illustrated book is an excellent resource on nucleic acid and protein-based technologies and metabolic profiling by analytic means or mass spectroscopy as well as for study designs for tumor biomarker discovery and validation. The audience includes both researchers interested in the identification and development of new tumor biomarkers and clinicians who need to be familiar with these new technologies in order to … treat cancer patients. In addition to researchers and clinicians, students interested in tumor biomarkers will find this book extremely useful.” (Omer Iqbal, Doody’s Review Service, January, 2010)