Quantitative Imaging Tools for Lung Cancer Drug Assessment

James L. Mulshine, MD, is a Professor of Internal Medicine, Associate Provost of Research and Vice President, Rush University Medical Center in Chicago, Illinois.?In this position, Dr. Mulshine is the primary academic officer responsible for managing research activities at Rush University Medical School. He is an internationally recognized expert on lung cancer.?Over the last few years, Dr. Mulshine has been working with a range of organizations to accelerate the use of high resolution spiral CT in the quantitative evaluation of drug response for early lung cancer.

Preface (Thomas M. Baer and James L. Mulshine). Chapter 1: Incorporating Imaging into Drug Development: An Industry Perspective (Philip S. Murphy and Debasish Roychowdhury).

Chapter 2: Developing Imaging Tools for Drug Development: Critical Technology, Clinical Data and Regulatory (Rafal Dziadziuszko, Fred R. Hirsch and Paul A. Bunn, Jr).

Chapter 3: Quantitative Imaging in CT Lung Cancer Drug Development and Evaluation (Ricardo S. Avila).

Chapter 4: Volumetric CT Imaging for Response Assessment in Lung Cancer: A Platform for Translational Research (Binsheng Zhao and Lawrence H. Scwhartz).

Chapter 5: Emerging Radiological Software Standards and Development Technologies: Impact on Clinical Translation and Trials (John Pearson, Lawrence Tarbox, Gianluca Paladini, John G. Wolodzko, Paula M. Jacobs, and Zhenghong Lee).

Chapter 6: Statistical Considerations Underlying Therapeutic Response Criteria for Lung Cancer: A Review in the Context of Emergence of Multi-Slice CT Scanner and Computer Assisted Diagnostic Algorithm for Volumetric Assessment (Madhu Mazumdar and Xi Kathy Zhou).

Chapter 7: Programs Supporting Quantitative Imaging in Biomedicine at the National Institute for Standards and Technology (Thomas M. Baer and Charles W. Clark).

Appendix A: Evolving Imaging Resources: Public Access Databases (Laurence Clarke).

Appendix B: Biomedical Imaging Archive Network (Thomas M. Baer and James L. Mulshine).

Appendix C: Developing CT Image-Processing Tools to Accelerate Progress in Lung Cancer Drug Development (James L. Mulshine, Ricardo S. Avila, Fred R. Hirsch, and David Yankelevitz).