Platelets

Dr. Michelson is Professor of Pediatrics and Professor of Medicine at Harvard Medical School in Boston, Massachusetts, U.S.A. He is also the Director of the Center for Platelet Research Studies (www.platelets.org) and the Director of the Thrombosis and Anticoagulation Program at Dana-Farber/Boston Children's Cancer and Blood Disorders Center. After receiving his medical degree with honors from the University of Adelaide, Australia, Dr. Michelson continued his medical and research training on a Fulbright Scholarship at Boston Children’s Hospital, Brigham and Women’s Hospital, and Harvard Medical School. In 2019 he received the International Society on Thrombosis and Haemostasis (ISTH) Esteemed Career Award. Dr. Michelson has been an invited participant in numerous National Institutes of Health working groups, international workshops and consensus conferences. He is the co-organizer and co-chair of the biennial International Platelets Symposium. Dr. Michelson is a past Chairman of the Platelet Physiology Scientific Subcommittee of the ISTH. He has published more than 450 original research articles, original research abstracts, and invited reviews – nearly all on the topic of platelets. Dr. Michelson has been the principal investigator on more than 100 research grants. He has been an invited speaker at over 200 major medical conferences worldwide. Dr. Michelson is an inventor on two awarded and three provisional U.S. patents.

Part One: Platelet Biology 1. The Evolution of Mammalian Platelets 2. Megakaryocyte Development and Platelet Formation 3. Platelet Structure 4. The Platelet Cytoskeleton 5. Platelet Genomics and Proteomics 6. Platelet Receptors 7. The Glycoprotein Ib-IX-V Complex 8. Integrin aIIbß3 9. Thrombin Receptors 10. The Platelet P2 Receptors 11. PECAM-1 12. P-Selectin/PSGL-1 and Other Interactions Between Platelets, Leukocytes, and Endothelium 13. Inhibition of Platelet Function by the Endothelium 14. Platelet Polymorphisms 15. Platelet Secretion 16. Signal Transduction During the Platelet Plug Formation 17. Outside-in Signaling By Integrin aIIbß3 18. Platelet Thrombus Formation in Flowing Blood 19. Interactions Between Platelets and the Coagulation System 20. Platelet-Derived Microparticles 21. The Role of Platelets in Fibrinolysis 22. Platelet Function in the Newborn

Part Two: Tests of Platelet Function 23. Clinical Tests of Platelet Function 24. Platelet Counting 25. The Bleeding Time 26. Platelet Aggregation 27. The VerifyNow System 28. Platelet Function Analyzer (PFA)-100 29. Impact Cone and Plate(let) Analyzer 30. Flow Cytometry 31. Thromboxane Generation 32. Perfusion Chambers 33. Animal Models 34. Real Time In Vivo Imaging of Platelets During Thrombus Formation

Part Three: The Role of Platelets in Disease 35. Atherothrombosis and Coronary Artery Disease 36. Central Nervous System Ischemia 37. Peripheral Vascular Disease 38. Diabetes Mellitus 39. Inflammation 40. Antimicrobial Host Defense 41. Angiogenesis 42. Tumor Growth and Metastasis 43. Alzheimer’s Disease 44. Psychiatric Disorders

Part Four: Disorders of Platelet Number and Function 45. The Clinical Approach to Disorders of Platelet Number and Function 46. Immune Thrombocytopenic Purpura 47. HIV-1-related Thrombocytopenia 48. Heparin-induced Thrombocytopenia 49. Drug-induced Thrombocytopenia 50. Thrombotic Thrombocytopenic Purpura and the Hemolytic-Uremic Syndrome 51. Thrombocytopenia in Pregnancy 52. Thrombocytopenia in the Newborn 53. Alloimmune Thrombocytopenia 54. Inherited Thrombocytopenias 55. Pseudothrombocytopenia 56. Thrombocytosis and Essential Thrombocythemia 57. Inherited Disorders of Platelet Function 58. Acquired Disorders of Platelet Function 59. Cardiopulmonary Bypass

Part Five: Pharmacology: Antiplatelet Therapy 60. Aspirin 61. ADP Receptor Antagonists 62. aIIbß3 (GPIIb-IIIa) Antagonists 63. Dipyridamole 64. Cilostazol 65. Experimental Antiplatelet Therapy

Part Six: Pharmacology: Therapy to Increase Platelet Numbers and/or Function 66. Platelet Growth Factors 67. Desmopressin (DDAVP) 68. Factor VIIa

Part Seven: Platelet Transfusion Medicine 69. Platelet Storage and Transfusion 70. Platelet Substitutes and Novel Methods of Platelet Preservation

Part Eight: Gene Therapy for Platelet Disorders 71. Gene Therapy for Platelet Disorders