Platelets

Dr. Michelson is Professor of Pediatrics and Professor of Medicine at Harvard Medical School in Boston, Massachusetts, U.S.A. He is also the Director of the Center for Platelet Research Studies (www.platelets.org) and the Director of the Thrombosis and Anticoagulation Program at Dana-Farber/Boston Children's Cancer and Blood Disorders Center. After receiving his medical degree with honors from the University of Adelaide, Australia, Dr. Michelson continued his medical and research training on a Fulbright Scholarship at Boston Children’s Hospital, Brigham and Women’s Hospital, and Harvard Medical School. In 2019 he received the International Society on Thrombosis and Haemostasis (ISTH) Esteemed Career Award. Dr. Michelson has been an invited participant in numerous National Institutes of Health working groups, international workshops and consensus conferences. He is the co-organizer and co-chair of the biennial International Platelets Symposium. Dr. Michelson is a past Chairman of the Platelet Physiology Scientific Subcommittee of the ISTH. He has published more than 450 original research articles, original research abstracts, and invited reviews – nearly all on the topic of platelets. Dr. Michelson has been the principal investigator on more than 100 research grants. He has been an invited speaker at over 200 major medical conferences worldwide. Dr. Michelson is an inventor on two awarded and three provisional U.S. patents.

ForewordA Brief History of Ideas About Platelets in Health and Disease

Part One: Platelet Biology1. The Evolution of Mammalian Platelets2. Megakaryocyte Development and Platelet Formation3. The regulation of platelet life span4. Platelet Genomics 5. Platelet MicroRNAs6. The Platelet Proteome 7. Platelet Structure8. The Platelet Cytoskeleton9. Platelet Receptors 10. The GPIb-IX-V Complex 11. GPVI and CLEC-212. Integrin AlphaIIb Beta3 13. Protease-activated Receptors 14. The Platelet P2 Receptors15. PECAM-116. Interactions Between Platelets, Leukocytes and the Endothelium17. Inhibition of Platelet Function by the Endothelium18. Platelet Secretion19. Signal Transduction During Platelet Plug Formation20. Platelet Thrombus Formation in Flowing Blood21. Interactions Between Platelets and the Coagulation System 22. Platelet-Derived Microparticles23. The Role of Platelets in Fibrinolysis24. The Role of Platelets in Angiogenesis 25. Platelet Function in the Newborn

Part Two: Tests of Platelet Function26. Clinical Tests of Platelet Function27. Platelet Counting28. Platelet Aggregation29. Flow Cytometry30. Monitoring of Antiplatelet Therapy31. Real Time In Vivo Imaging of Platelets During Thrombus Formation

Part Three: The Role of Platelets in Disease32. Atherothrombosis and Coronary Artery Disease 33. Central Nervous System Ischemia 34. Peripheral Vascular Disease35. Diabetes Mellitus36. Inflammation 37. Antimicrobial Host Defense38. Tumor Growth and Metastasis

Part Four: Disorders of Platelet Number and Function39. The Clinical Approach to Disorders of Platelet Number and Function 40. Immune Thrombocytopenia (ITP)41. Drug-induced Thrombocytopenia42. Heparin-induced Thrombocytopenia 43. Thrombotic Thrombocytopenic Purpura and the Hemolytic-Uremic Syndrome44. Thrombocytopenia in Pregnancy45. Thrombocytopenia in the Newborn46. Alloimmune Thrombocytopenia47. Inherited Thrombocytopenias 48. Pseudothrombocytopenia 49. Thrombocytosis and Essential Thrombocythemia50. Congenital Disorders of Platelet Function 51. Acquired Disorders of Platelet Function52. Cardiopulmonary Bypass

Part Five: Antiplatelet Therapy53. Aspirin 54. ADP Receptor Antagonists 55. AlphaIIb Beta3 (GPIIb-IIIa) Antagonists56. Dipyridamole57. Cilostazol58. Novel Antiplatelet Therapies

Part Six: Therapy to Increase Platelet Numbers and/or Function59. Thrombopoietin Mimetics 60. Desmopressin61. Factor VIIa62. Platelet Transfusion Medicine63. Making Platelets Ex Vivo 64. Gene Therapy for Platelet Disorders