Memory Loss

Andrew E. Budson, M.D. is Chief of Cognitive & Behavioral Neurology, Associate Chief of Staff for Education, and Director of the Center for Translational Cognitive Neuroscience at the Veterans Affairs (VA) Boston Healthcare System, Associate Director for Research at the Boston University Alzheimer's Disease Center, Professor of Neurology at Boston University School of Medicine, and Lecturer in Neurology at Harvard Medical School. He is also the Medical Director of the Boston Center for Memory, located in Newton, Massachusetts. His training included graduating cum laude from Harvard Medical School, being chief resident of the Harvard-Longwood Neurology Residency Program, pursuing a fellowship in dementia at Brigham and Women's Hospital, and studying memory as a post-doctoral fellow in experimental psychology and cognitive neuroscience at Harvard University. Dr. Budson has had government research funding since 1998, receiving a National Research Service Award and a Career Development Award in addition to a Research Project (R01) grant. He has given over 425 local, national, and international grand rounds and other academic talks. He has published over 100 papers, reviews, and book chapters and is a reviewer for more than 40 journals. He has co-authored or edited five books, including Memory Loss, Alzheimer's Disease, and Dementia: A Practical Guide for Clinicians, the second edition of which has been translated into Spanish, Portuguese, and Japanese. He was awarded the Norman Geschwind Prize in Behavioral Neurology in 2008 and the Research Award in Geriatric Neurology in 2009, both from the American Academy of Neurology. His current research uses the techniques of experimental psychology and cognitive neuroscience to understand memory in patients with Alzheimer's disease. In his memory disorders clinic at the VA Boston Healthcare System he treats patients while teaching fellows, residents, and medical students. He also sees patients in Newton at the Boston Center for Memory Dr. Paul Solomon is a founder and the Director of the Boston Center for Memory in Newton, MA. He specializes in Clinical Neuropsychology and Clinical Neuroscience. Dr. Solomon is also an Investigator of the Boston University Alzheimer's Disease Center, Boston University School of Medicine. Dr. Solomon has received numerous awards including a Distinguished Teaching Award from the University of Massachusetts, a National Research Service Award from the National Institutes of Health, and a National Needs Postdoctoral Fellowship from the National Science Foundation, and two clinical research awards from the American Association of Family Physicians. He has been elected as a Fellow of the American Association for the Advancement of Science, the American Psychological Association and the American Psychological Society. He is listed in Who's Who in America, American Men and Women of Science, Who's Who in Education, and Who's Who in Frontier Science and Technology. Dr. Solomon has served on the Editorial Board of several journals and serves as an external reviewer for numerous journals and granting agencies. He has served on the advisory boards of the Northeastern New York Alzheimer's Association and the MA/NH Chapter Alzheimer's Association. He has delivered more than 500 lectures nationally and internationally widely at colleges and universities on age-related memory disorders and at medical centers and hospitals on the diagnosis and treatment of Alzheimer's disease.

SECTION I EVALUATING THE PATIENT WITH MEMORY LOSS CHAPTER 1 Why Diagnose and Treat?...1 CHAPTER 2 Evaluating the Patient with Memory Loss ...4 SECTION II DIFFERENTIAL DIAGNOSIS OF MEMORY LOSS CHAPTER 3 Alzheimer's Disease...43 CHAPTER 4 Mild Cognitive Impairment ...71 CHAPTER 5 Dementia with Lewy Bodies (Including Parkinson's Disease Dementia) ...79 CHAPTER 6 Vascular Dementia and Vascular Cognitive Impairment ...91 CHAPTER 7 Frontotemporal Dementia...104 CHAPTER 8 Progressive Supranuclear Palsy ...118 CHAPTER 9 Corticobasal Degeneration ...128 CHAPTER 10 Normal Pressure Hydrocephalus...136 CHAPTER 11 Creutzfeldt-Jakob Disease...143 CHAPTER 12 Other Disorders...148 SECTION III TREATMENT OF MEMORY LOSS CHAPTER 13 Goals of Treatment...163 CHAPTER 14 Cholinesterase Inhibitors...166 CHAPTER 15 Memantine (Namenda) ...184 CHAPTER 16 Vitamins, Herbs, Supplements, and Anti-Inflammatories...193 CHAPTER 17 Future Treatments of Memory Loss ...199 CHAPTER 18 Non-Pharmacological Treatment of Memory Loss ...214 SECTION IV BEHAVIORAL AND PSYCHOLOGICAL SYMPTOMS OF DEMENTIA CHAPTER 19 Evaluating the Behavioral and Psychological Symptoms of Dementia...220 CHAPTER 20 Caring for and Educating the Caregiver...228 CHAPTER 21 Non-Pharmacological Treatment of the Behavioral and Psychological Symptoms of Dementia ...236 CHAPTER 22 Pharmacological Treatment of the Behavioral and Psychological Symptoms of Dementia...247 SECTION V ADDITIONAL ISSUES CHAPTER 23 Life Adjustments ...259 CHAPTER 24 Legal and Financial Issues...266 CHAPTER 25 Special Issues...271 SECTION VI CASE STUDIES...275 ONLINE ONLY APPENDICES: (See inside front cover for details) APPENDIX A Cognitive Test and Questionnaire Forms, Instructions, and Normative Data APPENDIX B Screening for Memory Loss APPENDIX C Our Current Understanding of Memory Index...289