Tissue Oxygenation in Acute Medicine

This text is a compilation of papers developed for the annual Round Table Conference of the Brussels Emergency and Intensive Care meeting. Bringing together researchers from many disciplines, with both basic and clinical perspectives, this meeting reviewed and debated issues pertaining to the control of tissue oxygenation in acute medicine, as well as treatments to improve tissue oxygenation when abnormal. In this latter context, special emphasis was placed on understanding the effect of blood substitutes on the circulation, and the potential roles of this family of compounds in clinical medicine.
TOC: From the Contents: Role of Cardiorespiratory System in Delivering Oxygen.- The Microcirculation and Tissue Oxygenation.- Oxygen Signaling Cascades in Mammalian Cells.- The Mitochondrial Permeability Transition.- Hypoxic Hypoxia.- Circulatory Hypoxia.- Anemic Hypoxia.- Cellular Responses to Hypoxia: Possible Relevance to Multiple Organ Failure in Critical Illness.- Measuring Tissue Oxygenation I: The Available Clinical Tools - Oxygen-derived Variables, Lactate and pHi.- The Optimal and Critical Hemoglobin in Health and Acute Illness.- Perfluorcarbones as Oxygen Carriers.-