Mechanisms of Adaptation and Reconstruction in the Hypoperfused Brain - Melanie Tamara Carolin Kuffner

Mechanisms of Adaptation and Reconstruction in the Hypoperfused Brain

Buch | Softcover
72 Seiten
2024
BoD – Books on Demand (Verlag)
978-3-7597-4874-4 (ISBN)
12,95 inkl. MwSt
This book delves into the molecular mechanisms after stroke and gives an overview about current findings in ameliorating the recovery phase. It provides insights into post-ischemic recovery processes and illustrates novel findings of targets for therapeutic interventions for brain ischemia.

Focus topics are microenvironmental changes mediated by the molecules interleukin 6 (IL-6) and SorCS2 in murine models of ischemia. One particular focus of the book is the evaluation of the effect of the inflammatory cytokine IL-6 on the brain parenchyma in carotid stenosis, a chronic form of brain ischemia. IL-6 plays an ambivalent role in the hypoperfused brain. The study in this book shows that on a network and molecular level, IL-6 can mediate potentially beneficial changes and provides potential therapeutic targets for continuing research.

In a second study, the role of SorCS2 in stroke is analyzed, providing new insights into the role of this sorting protein in stroke recovery.

By shining light on the prediction of humane endpoints in ischemic mouse models, this book also shines light on the 3R approach of reducing animal suffering in experimental research.

Melanie Kuffner (PhD) is a neuroscientist and expert for pre-clinical stroke research. She received her doctoral degree from Charité Universitätsmedizin Berlin where she worked in the Department of Experimental Neurology led by Prof. Ulrich Dirnagl.

Erscheinungsdatum
Sprache englisch
Maße 155 x 220 mm
Gewicht 130 g
Themenwelt Medizin / Pharmazie Medizinische Fachgebiete Biomedizin
Medizin / Pharmazie Medizinische Fachgebiete Neurologie
Schlagworte brain • Ischemia • Neurology • Regeneration • stroke
ISBN-10 3-7597-4874-0 / 3759748740
ISBN-13 978-3-7597-4874-4 / 9783759748744
Zustand Neuware
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