Gastrointestinal Oncology

Janusz Jankowski MD, PhD, FRCP, FACG Consultant Gastroenterologist, Digestive Diseases Centre UHL Trust, Leicester, UK James Black Senior Fellow and Professor, University of Oxford, UK Fellow and Professor, Cancer Research UK and Queen Mary University of London, UK Richard Sampliner MD Professor of Medicine, University of Arizona College of Medicine, USA Chief of Gastroenterology, Southern Arizona VA Health Care System, USA David Kerr CBE, MA, MD, DSc, FRCP, FMedSci Rhodes Professor of Cancer Therapeutics and Clinical Pharmacology, University of Oxford, UK Head of Department of Clinical Pharmacology, University of Oxford, UK Yuman Fong MD Murray F. Brennan Chair in Surgery, Memorial Sloan-Kettering Cancer Center, New York, USA Professor of Surgery, Weill Cornell Medical Center, New York, USA

List of Contributors ix

Preface xvi

Foreword xvii

Part 1: Gastroesophageal Cancer
Edited by Richard Sampliner

1 Epidemiology of Gastroesophageal Cancer 3
Evan S. Dellon & Nicholas J. Shaheen

2 Factors involved in Carcinogenesis and Prevention 14
Mark R. Anderson & Janusz Jankowski

3 Molecular Biology of Gastroesophageal Cancers: the Role of Mutational Analysis in Prognosis 21
Matthew Lovell, Chetan Bhan, Janusz Jankowski & Stuart McDonald

4 Esophageal Adenocarcinoma 31
Edited by Kenneth K. Wang

5 Squamous Cancer of the Esophagus 114
Edited by Hugh Barr

6 Diffuse Gastric Cancer 146
Edited by Ilfet Songun & Cornelius van de Velde

7 Intestinal Gastric Cancer 177
Edited by Benjamin C.Y. Wong

8 Small Bowel Tumors 189
Edited by Nadir Arber

9 Sarcoma and Gastrointestinal Stromal Tumors 227
Edited by Markku Miettinen

10 Rare Tumors of the Abdomen 259
Edited by Anil R. Prasad

Part 2: Colorectal Cancer
Edited by David Kerr

11 Epidemiology and Prevention of Colorectal Cancer 293
Paul Moayyedi

12 The Molecular Pathology of Sporadic and Hereditary Colorectal Cancer 305
Massimo Pignatelli, Nahida Banu & Zsombor Melegh

13 Screening for Colorectal Cancer 317
Robert J.C. Steele

14 Cancer of the Colon and Rectum 325
Edited by Rachel S. Midgley

15 Rare Cancers 374
Edited by Colin McArdle

Part 3: Hepatobiliary Cancer
Edited by Yuman Fong

16 Epidemiology of Hepatocellular Carcinoma 411
Hashem B. El-Serag, Donna L. White & Zhannat Nurgalieva

17 Factors involved in Carcinogenesis and Prevention in Hepatobiliary Cancer 421
Paula Ghaneh, William Greenhalf & John P. Neoptolemos

18 Molecular Biology of Hepatobiliary Cancer 433
Knut Ketterer & Helmut Friess

19 Primary Liver Cancer 441
Edited by Charlie Pan & Theodore Lawrence

20 Metastatic Liver Cancer 469
Edited by Yuman Fong

21 Primary Pancreatic Adenocarcinoma 498
Edited by Christopher L. Wolfgang

22 Cholangiocarcinoma 543
Edited by Ravi S. Chari

23 Neuroendocrine Tumors 564
Edited by Ursula Plöckinger

24 Rare Tumors of the Liver 669
Shantanu Bhattacharjya, Zahir Soonawalla, Rachel R. Phillips & Peter J. Friend

25 Cystic Neoplasms of the Pancreas 688
Edited by Peter J. Allen

Index 711