Gastrointestinal Oncology

Janusz A. Z. Jankowski, MB ChB, MSc, MD, PhD, AGAF, FRCP, FRCPE, FACG, SFHEA, PGCC, PGCE, PGCM, JP, is a doctor, educator, scientist, executive coach, and policy expert who has held numerous clinical, educational, research and administrative roles, including as Provost/Dean in the United Arab Emirates, Associate Dean at the Peninsula Medical School, UK, and the Sir James Black Senior Fellow and Honorary Professor at the University of Oxford, UK. He has also served as the Chair of Education for the British Society of Gastroenterology as well as a Regional Director of Postgraduate Training in Medical Education in England. He also serves as a Consultant Physician, Gastroenterologist, Lead Mentor and Non-Executive Director for the National Health Service, UK as well as being an Honorary Clinical Professor at University College London. In addition, he has been a government clinical advisor to both the National Institute for Health and Care Excellence (NICE), UK, and overseas healthcare organisations as well as serving on Family Law and Medical Panels.

List of Contributors , vii

Preface , xvii

Foreword , xviii

Section I: Upper Gastrointestinal Cancer, 1

1 Epidemiology, Microbiome, and Risk Factors Involved in Carcinogenesis of Esophagus, Gastric, and Intestine, 3

2 Genomics, Molecular Pathology, and Pathology of Esophageal and Gastric Cancer, 23

3 Screening, Surveillance, and Prevention of Esophageal and Gastric Cancers, 42

4 Management of Esophageal Dysplasia and Esophageal Adenocarcinoma, 63

5 Esophageal Squamous Cell Carcinoma, 82

6 Management of Diffuse Gastric Cancer, 116

7 Intestinal-type Gastric Cancer, 120

8 Cancer of the Small Intestine, 139

Section II: Colorectal and Anal Cancer, 145

9 Epidemiology, Microbiome, and Risk Factors Involved in Carcinogenesis of Colorectal Cancer, 147

10 Genomics, Histopathology, and Molecular Pathology of Sporadic and Hereditary Colorectal Cancer, 149

11 Screening, Surveillance, and Prevention for Colorectal Cancer, 170

12 Colorectal Cancer, 181

13 Epidemiology, Pathology, Diagnosis, Prevention, and Management of Anal Cancer, 235

Section III: Hepatobiliary and Pancreas Cancer, 249

14 Epidemiology and Risk Factors of Hepatocellular Carcinoma, 251

15 Pathology, Molecular Pathology, and Genomics of Hepatobiliary and Pancreatic Cancer, 264

16 Screening, Surveillance, and Prevention of Hepatocellular Carcinoma, 271

17 Pancreatic and Biliary Tract Cancers: Risk Factors and Etiology, Screening, Surveillance, and Biomarkers of Detection and Prognosis, 291

18 The Multidisciplinary Management of Primary Hepatocellular Carcinoma, 321

19 Management of Metastatic Liver Cancer, 347

20 Management of Primary Pancreatic Cancer, 386

21 Management of Intrahepatic and Extrahepatic Cholangiocarcinoma, 407

22 Management of Cystic Neoplasms of the Pancreas, 438

Section IV: Specialist Abdominal Cancer Management teams, 455

23 Epidemiology, Pathology, Diagnosis, Prevention, and Management of GI Stromal Tumors and Other GI Sarcomas, 457

24 Neuroendocrine Neoplasms of the Digestive System, 470

25 Epidemiology, Pathology, Diagnosis, Prevention, and Management of Unknown Primary Cancer, 538

26 Diagnosis and Management of Gastrointestinal Lymphomas, 546

27 Palliative and Supportive Medicine in Gastrointestinal Oncology, 561

28 Psychological Oncology and Wellbeing: Wellbeing (part 1) and narrative practices in child palliative care (part 2), 576

29 Nutrition for Cancer Prevention, Adjunctive Cancer Care, and Rehabilitation: Nutrition and Cancer, 587

Cancer – The Road Less Traveled, 591

Index, 593